Haemolysis and abnormal haemorheology in sickle cell anaemia

Philippe Connes, Yann Lamarre, Xavier Waltz, Samir K. Ballas, Nathalie Lemonne, Maryse Etienne-Julan, Olivier Hue, Marie Dominique Hardy-Dessources, Marc Romana

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Although pulmonary hypertension, leg ulcers, priapism, stroke and glomerulopathy in sickle cell anaemia (SCA) result from the adverse effects of chronic haemolysis on vascular function (haemolytic phenotype), osteoneocrosis, acute chest syndrome and painful vaso-occlusive crises are caused by abnormal vascular cell adhesion and increased blood viscosity (viscosity-vaso-occlusion phenotype). However, this model with two sub-phenotypes does not take into account the haemorheological dimension. We tested the relationships between the biological parameters reflecting the haemolytic rate (haemolytic component) and red blood cell (RBC) rheological characteristics in 97 adults with SCA. No significant difference in the proportion of patients with low or high haemolytic component in the low and high blood viscosity groups was observed. The RBC elongation index (i.e. deformability) was negatively correlated with the haemolytic component. The RBC aggregates strength (i.e. RBC aggregates robustness) was negatively correlated with RBC elongation index. Sickle RBCs with high density had lower elongation index and higher aggregates strength. In conclusion, (i) the 'haemolytic' phenotype is characterized by decreased RBC deformability and increased RBC aggregates strength and (ii) the viscosity-vaso-occlusive phenotype is characterized by increased RBC deformability but not always by increased blood viscosity. α-thalassaemia modulates the haemorheological properties but other factors seem to be involved.

Original languageEnglish (US)
Pages (from-to)564-572
Number of pages9
JournalBritish journal of haematology
Volume165
Issue number4
DOIs
StatePublished - May 2014

Keywords

  • Haemolysis
  • Haemorheology
  • Sickle cell disease

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