TY - GEN
T1 - Hand-held high-throughput ultrasonic monodisperse aerosol inhalers for detoxification of massive cyanide poisoning
AU - Tsai, Chen S.
AU - Mao, Rong W.
AU - Zhu, Yun
AU - Chien, Eric
AU - Maduzia, James
AU - Tsai, Shirley C.
AU - Brenner, Matthew
AU - Mahon, Sari
AU - Mukai, David
AU - Lee, Jangwoen
AU - Yoon, David
AU - Berney, Tanya
AU - Boss, Gerry
AU - Patterson, Steve
PY - 2012
Y1 - 2012
N2 - Detoxification of massive cyanide (CN) poisoning by inhalation of antidotes is recognized to be superior to intra venous (IV) or intra muscular (IM) treatment with regard to ease of administration, self-administration, and rapidity of onset. However, there are currently no effective, portable, high-throughput inhalers that can be produced in large quantities and distributed for such purpose. A hand-held inhaler has been realized using silicon-based ultrasonic nozzle to produce high-throughput of monodisperse cobinamide antidote solution for detoxification of CN poisoning in a rabbit model.
AB - Detoxification of massive cyanide (CN) poisoning by inhalation of antidotes is recognized to be superior to intra venous (IV) or intra muscular (IM) treatment with regard to ease of administration, self-administration, and rapidity of onset. However, there are currently no effective, portable, high-throughput inhalers that can be produced in large quantities and distributed for such purpose. A hand-held inhaler has been realized using silicon-based ultrasonic nozzle to produce high-throughput of monodisperse cobinamide antidote solution for detoxification of CN poisoning in a rabbit model.
KW - Fourier-horn ultrasonic nozzles
KW - cobinamide antidote
KW - cyanide poisoning and detoxification
KW - monodisperse aerosol inhaler
UR - http://www.scopus.com/inward/record.url?scp=84881530483&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84881530483&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2012.0409
DO - 10.1109/ULTSYM.2012.0409
M3 - Conference contribution
AN - SCOPUS:84881530483
SN - 9781467345613
T3 - IEEE International Ultrasonics Symposium, IUS
SP - 1632
EP - 1634
BT - 2012 IEEE International Ultrasonics Symposium, IUS 2012
T2 - 2012 IEEE International Ultrasonics Symposium, IUS 2012
Y2 - 7 October 2012 through 10 October 2012
ER -