Bibliographical noteFunding Information:
Work in the authors' laboratories is supported by funds from CICYT (PB95-1131), Gener-alitat de Catalunya \[Grup Consolidat (1995SGR 494) i Centre de Refer~ncia en Biotecnologia\], the National Institutes of Health (GM-09708), and the National Science Foundation (CHE-9314038).
We thank our co-workers and colleagues, in particular Drs. Fernando Albericio and Steve Kates, for sharing experiences with handles and other aspects of solid-phase peptide synthesis. Preparation of this review and supporting experimental work were supported by the National Institutes of Health (GM 42722).