Head and neck cancers

Cherie Ann O. Nathan; Oleksandr Ekshyyan; Arunkumar Anandharaj

doi:10.1007/978-94-017-9078-9_25

Head and neck cancers

Cherie Ann O. Nathan, Oleksandr Ekshyyan, Arunkumar Anandharaj

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Recent evidence suggests that dysregulated translation and its control significantly contribute to the etiology and pathogenesis of the head and neck cancers, specifically to that of squamous cell carcinoma (HNSCC). eIF4E is one of the most studied components of the translation machinery implicated in the development and progression of HNSCC. It appears that dysregulation of eIF4E levels and activity, namely by the PI3K/AKT/mTOR pathway, plays an important role in the etiology and pathogenesis of HNSCC and correlates with clinical outcomes. In this chapter, we will discuss the role of eIF4E and some other translation factors as they relate to the biology and treatment of HNSCC.

Original language	English (US)
Title of host publication	Translation and Its Regulation in Cancer Biology and Medicine
Publisher	Springer Netherlands
Pages	499-512
Number of pages	14
ISBN (Electronic)	9789401790789
ISBN (Print)	9401790779, 9789401790772
DOIs	https://doi.org/10.1007/978-94-017-9078-9_25
State	Published - Mar 1 2014
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2014 Springer Science+Business Media Dordrecht. All rights reserved.

Keywords

Biomarker
Head and neck cancer
Head and neck squamous cell carcinoma (HNSCC)
MNK
Targeted therapy
Therapeutic resistance
Translation
Tumor margin
eIF4E
mTOR pathway

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1007/978-94-017-9078-9_25

OpenUrl availability

Full text

Cite this

@inbook{73eb76b140ab40f3964af61f2a0688ac,

title = "Head and neck cancers",

abstract = "Recent evidence suggests that dysregulated translation and its control significantly contribute to the etiology and pathogenesis of the head and neck cancers, specifically to that of squamous cell carcinoma (HNSCC). eIF4E is one of the most studied components of the translation machinery implicated in the development and progression of HNSCC. It appears that dysregulation of eIF4E levels and activity, namely by the PI3K/AKT/mTOR pathway, plays an important role in the etiology and pathogenesis of HNSCC and correlates with clinical outcomes. In this chapter, we will discuss the role of eIF4E and some other translation factors as they relate to the biology and treatment of HNSCC.",

keywords = "Biomarker, Head and neck cancer, Head and neck squamous cell carcinoma (HNSCC), MNK, Targeted therapy, Therapeutic resistance, Translation, Tumor margin, eIF4E, mTOR pathway",

author = "Nathan, {Cherie Ann O.} and Oleksandr Ekshyyan and Arunkumar Anandharaj",

year = "2014",

month = mar,

day = "1",

doi = "10.1007/978-94-017-9078-9_25",

language = "English (US)",

isbn = "9401790779",

pages = "499--512",

booktitle = "Translation and Its Regulation in Cancer Biology and Medicine",

publisher = "Springer Netherlands",

}

TY - CHAP

T1 - Head and neck cancers

AU - Nathan, Cherie Ann O.

AU - Ekshyyan, Oleksandr

AU - Anandharaj, Arunkumar

PY - 2014/3/1

Y1 - 2014/3/1

N2 - Recent evidence suggests that dysregulated translation and its control significantly contribute to the etiology and pathogenesis of the head and neck cancers, specifically to that of squamous cell carcinoma (HNSCC). eIF4E is one of the most studied components of the translation machinery implicated in the development and progression of HNSCC. It appears that dysregulation of eIF4E levels and activity, namely by the PI3K/AKT/mTOR pathway, plays an important role in the etiology and pathogenesis of HNSCC and correlates with clinical outcomes. In this chapter, we will discuss the role of eIF4E and some other translation factors as they relate to the biology and treatment of HNSCC.

AB - Recent evidence suggests that dysregulated translation and its control significantly contribute to the etiology and pathogenesis of the head and neck cancers, specifically to that of squamous cell carcinoma (HNSCC). eIF4E is one of the most studied components of the translation machinery implicated in the development and progression of HNSCC. It appears that dysregulation of eIF4E levels and activity, namely by the PI3K/AKT/mTOR pathway, plays an important role in the etiology and pathogenesis of HNSCC and correlates with clinical outcomes. In this chapter, we will discuss the role of eIF4E and some other translation factors as they relate to the biology and treatment of HNSCC.

KW - Biomarker

KW - Head and neck cancer

KW - Head and neck squamous cell carcinoma (HNSCC)

KW - MNK

KW - Targeted therapy

KW - Therapeutic resistance

KW - Translation

KW - Tumor margin

KW - eIF4E

KW - mTOR pathway

UR - http://www.scopus.com/inward/record.url?scp=84930906703&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930906703&partnerID=8YFLogxK

U2 - 10.1007/978-94-017-9078-9_25

DO - 10.1007/978-94-017-9078-9_25

M3 - Chapter

AN - SCOPUS:84930906703

SN - 9401790779

SN - 9789401790772

SP - 499

EP - 512

BT - Translation and Its Regulation in Cancer Biology and Medicine

PB - Springer Netherlands

ER -

Head and neck cancers

Abstract

Bibliographical note

Keywords

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this