Hemophilia B and free tissue transfer: Medical and surgical management

P. Daniel Knott, Samir S. Khariwala, Joseph Minarchek

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Hemophilia B (Christmas disease) is a rare, X-linked bleeding diathesis, which may present with life-threatening hemorrhage. Management of the coagulopathy in the setting of free tissue transfer may be particularly challenging. The authors present the first case in the English literature of a male with hemophilia B undergoing microvascular free flap reconstruction, as well as a review of the current surgical and medical management of hemophilia B. Based upon this experience, perioperative specific factor replacement is recommended. Given physiologic trough levels of the replaced factor, routine antiplatelet therapy appears appropriate. Management of free tissue transfer in the setting of severe hemophilia is significantly more challenging and should benefit from multidisciplinary coordination.

Original languageEnglish (US)
Pages (from-to)336-338
Number of pages3
JournalAnnals of Plastic Surgery
Issue number3
StatePublished - Mar 1 2005


  • Bleeding disorder
  • Blood dyscrasia
  • Hemophilia
  • Microvascular free tissue transfer
  • Reconstructive surgery

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