Hepatic lipid droplet biology: Getting to the root of fatty liver

Douglas G. Mashek; Salmaan A. Khan; Aishwarya Sathyanarayan; Jonathan M. Ploeger; Mallory P. Franklin

doi:10.1002/hep.27839

Hepatic lipid droplet biology: Getting to the root of fatty liver

Douglas G. Mashek, Salmaan A. Khan, Aishwarya Sathyanarayan, Jonathan M. Ploeger, Mallory P. Franklin

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Abstract

Hepatic steatosis is defined by the accumulation of lipid droplets (LDs). Once thought to be only inert energy storage depots, LDs are increasingly recognized as organelles that have important functions in hepatocytes beyond lipid storage. The lipid and protein composition of LDs is highly dynamic and influences their intrinsic metabolism and signaling properties, which ultimately links them to the changes in hepatic function. This concise review highlights recent discoveries in LD biology and unique aspects of hepatic LDs and their role in liver disease.

Original language	English (US)
Pages (from-to)	964-967
Number of pages	4
Journal	Hepatology
Volume	62
Issue number	3
DOIs	https://doi.org/10.1002/hep.27839
State	Published - Sep 1 2015

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© 2015 by the American Association for the Study of Liver Diseases.

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Hepatic lipid droplet biology: Getting to the root of fatty liver

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