Hepatocellular carcinoma in hepatitis-negative patients with thalassemia intermedia: A closer look at the role of siderosis

Joseph E. Maakaron; Maria Domenica Cappellini; Giovanna Graziadei; Jad Bou Ayache; Ali T. Taher

doi:10.1016/s1665-2681(19)31397-3

Hepatocellular carcinoma in hepatitis-negative patients with thalassemia intermedia: A closer look at the role of siderosis

Joseph E. Maakaron, Maria Domenica Cappellini, Giovanna Graziadei, Jad Bou Ayache, Ali T. Taher

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Patients with thalassemia are often exposed to several risk factors for developing hepatocellular carcinoma (HCC) due to their repeated transfusions. However, even transfusion-independent patients with thalassemia intermedia (TI) can develop HCC, which is mainly attributed to a state of iron overload. We report here two cases and review the literature for the association between TI and HCC. Along with our cases, a total of 36 cases of HCC in thalassemic patients were reported in the literature. Of these, 22 (61%) were TI patients with 6 (27%) of them being hepatitis B and C negative. There was no consistency in their characteristics; therefore, we recommended screening thresholds for HCC in TI patients based on their total liver iron concentration (LIC).

Original language	English (US)
Pages (from-to)	142-146
Number of pages	5
Journal	Annals of Hepatology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/s1665-2681(19)31397-3
State	Published - 2013
Externally published	Yes

Keywords

Hepatocellular carcinoma
Iron overload
Liver iron concentration
Risk factor
Thalassemia intermedia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1016/s1665-2681(19)31397-3

OpenUrl availability

Full text

Cite this

@article{1389f27152fa48e8b56b4a8c442ab610,

title = "Hepatocellular carcinoma in hepatitis-negative patients with thalassemia intermedia: A closer look at the role of siderosis",

abstract = "Patients with thalassemia are often exposed to several risk factors for developing hepatocellular carcinoma (HCC) due to their repeated transfusions. However, even transfusion-independent patients with thalassemia intermedia (TI) can develop HCC, which is mainly attributed to a state of iron overload. We report here two cases and review the literature for the association between TI and HCC. Along with our cases, a total of 36 cases of HCC in thalassemic patients were reported in the literature. Of these, 22 (61%) were TI patients with 6 (27%) of them being hepatitis B and C negative. There was no consistency in their characteristics; therefore, we recommended screening thresholds for HCC in TI patients based on their total liver iron concentration (LIC).",

keywords = "Hepatocellular carcinoma, Iron overload, Liver iron concentration, Risk factor, Thalassemia intermedia",

author = "Maakaron, {Joseph E.} and Cappellini, {Maria Domenica} and Giovanna Graziadei and Ayache, {Jad Bou} and Taher, {Ali T.}",

year = "2013",

doi = "10.1016/s1665-2681(19)31397-3",

language = "English (US)",

volume = "12",

pages = "142--146",

journal = "Annals of Hepatology",

issn = "1665-2681",

publisher = "Mexican Association of Hepatology",

number = "1",

}

TY - JOUR

T1 - Hepatocellular carcinoma in hepatitis-negative patients with thalassemia intermedia

T2 - A closer look at the role of siderosis

AU - Maakaron, Joseph E.

AU - Cappellini, Maria Domenica

AU - Graziadei, Giovanna

AU - Ayache, Jad Bou

AU - Taher, Ali T.

PY - 2013

Y1 - 2013

N2 - Patients with thalassemia are often exposed to several risk factors for developing hepatocellular carcinoma (HCC) due to their repeated transfusions. However, even transfusion-independent patients with thalassemia intermedia (TI) can develop HCC, which is mainly attributed to a state of iron overload. We report here two cases and review the literature for the association between TI and HCC. Along with our cases, a total of 36 cases of HCC in thalassemic patients were reported in the literature. Of these, 22 (61%) were TI patients with 6 (27%) of them being hepatitis B and C negative. There was no consistency in their characteristics; therefore, we recommended screening thresholds for HCC in TI patients based on their total liver iron concentration (LIC).

AB - Patients with thalassemia are often exposed to several risk factors for developing hepatocellular carcinoma (HCC) due to their repeated transfusions. However, even transfusion-independent patients with thalassemia intermedia (TI) can develop HCC, which is mainly attributed to a state of iron overload. We report here two cases and review the literature for the association between TI and HCC. Along with our cases, a total of 36 cases of HCC in thalassemic patients were reported in the literature. Of these, 22 (61%) were TI patients with 6 (27%) of them being hepatitis B and C negative. There was no consistency in their characteristics; therefore, we recommended screening thresholds for HCC in TI patients based on their total liver iron concentration (LIC).

KW - Hepatocellular carcinoma

KW - Iron overload

KW - Liver iron concentration

KW - Risk factor

KW - Thalassemia intermedia

UR - http://www.scopus.com/inward/record.url?scp=84876284207&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876284207&partnerID=8YFLogxK

U2 - 10.1016/s1665-2681(19)31397-3

DO - 10.1016/s1665-2681(19)31397-3

M3 - Article

C2 - 23293206

AN - SCOPUS:84876284207

SN - 1665-2681

VL - 12

SP - 142

EP - 146

JO - Annals of Hepatology

JF - Annals of Hepatology

IS - 1

ER -

Hepatocellular carcinoma in hepatitis-negative patients with thalassemia intermedia: A closer look at the role of siderosis

Abstract

Keywords

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this