The protection inducing capacity of Toxocara canis, Ancylostoma caninum, Haemonchus contortus, Caenorhabditis briggsae and Turbatrix aceti given via the mesenteric vein to a challenge infection with Ascaris suum was evaluated. Embryonated eggs and second stage larvae of T. canis and infective larvae of A. caninum were able to induce a statistically significant level of protective immunity, while the other non-related helminths were unable to protect against a challenge infection.
Bibliographical noteFunding Information:
The authors thank Dr T. Miller, Jensen-SalberyL aboratoriesK, ansasCity, Kansas, for the third stage larvae of A. caninum and Dr E.L. Hansen, Clinical PharmacologyR esearchI nstitute,Berkeley, California, for the C. briggsae. We also thank Miss Norma Molina and Mrs Rosetta Goss for their technical assistance. This work was supported in part by USPHS ResearchTrainingGrant AI-00302 and ResearchG rant AI-06262.