HHLA2 and TMIGD2: new immunotherapeutic targets of the B7 and CD28 families

Murali Janakiram; Jordan M. Chinai; Aimin Zhao; Joseph A. Sparano; Xingxing Zang

doi:10.1080/2162402X.2015.1026534

HHLA2 and TMIGD2: new immunotherapeutic targets of the B7 and CD28 families

Murali Janakiram, Jordan M. Chinai, Aimin Zhao, Joseph A. Sparano, Xingxing Zang

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Abstract

We and others recently discovered HHLA2 as a new B7 family member and transmembrane and immunoglobulin domain containing 2 (TMIGD2) as one of its receptors. Based on a new study we propose that HHLA2 may represent a novel immunosuppressive mechanism within the tumor microenvironment and hence could be a target for cancer therapy. TMIGD2 may be another therapeutic target.

Original language	English (US)
Journal	OncoImmunology
Volume	4
Issue number	8
DOIs	https://doi.org/10.1080/2162402X.2015.1026534
State	Published - Aug 3 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 Taylor & Francis Group, LLC.

Keywords

B7 family
CD28 family
HHLA2
TMIGD2
angiogenesis
immunosuppression
immunotherapy
ligand
receptor
tumor microenvironment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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AU - Sparano, Joseph A.

AU - Zang, Xingxing

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HHLA2 and TMIGD2: new immunotherapeutic targets of the B7 and CD28 families

Abstract

Bibliographical note

Keywords

UN SDGs

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