Hierarchical organization of modularity in metabolic networks

E. Ravasz, A. L. Somera, D. A. Mongru, Z. N. Oltvai, A. L. Barabási

Research output: Contribution to journalArticlepeer-review

2777 Scopus citations

Abstract

Spatially or chemically isolated functional modules composed of several cellular components and carrying discrete functions are considered fundamental building blocks of cellular organization, but their presence in highly integrated biochemical networks lacks quantitative support. Here, we show that the metabolic networks of 43 distinct organisms are organized into many small, highly connected topologic modules that combine in a hierarchical manner into larger, less cohesive units, with their number and degree of clustering following a power law. Within Escherichia coli, the uncovered hierarchical modularity closely overlaps with known metabolic functions. The identified network architecture may be generic to system-level cellular organization.

Original languageEnglish (US)
Pages (from-to)1551-1555
Number of pages5
JournalScience
Volume297
Issue number5586
DOIs
StatePublished - Aug 30 2002

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