Abstract
The synthesis, photophysical and biological characterization of a small library of fluorescent 5-HT 3 receptor ligands is described. Several of these novel granisetron conjugates have high quantum yields and show high affinity for the human 5-HT 3AR.
Original language | English (US) |
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Pages (from-to) | 1151-1155 |
Number of pages | 5 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 22 |
Issue number | 2 |
DOIs | |
State | Published - Jan 15 2012 |
Externally published | Yes |
Bibliographical note
Funding Information:This research was supported by the Swiss National Science Foundation (SNSF-professorship PP00P2_123536 to ML), the EPSRC (EP/E042139/1) and the Wellcome Trust (085141 (CNC and JDH) and 081925/Z/07/Z (SCRL and AJT)). SCRL is a Wellcome Trust Senior Research Fellow in Basic Biomedical Science.
Keywords
- 5-HT receptor
- Cys-loop ligand-gated ion channels
- Fluorescent ligands
- In vivo imaging
- Radioligand binding