High-Density Lipoprotein Subclasses and Noncardiovascular, Noncancer Chronic Inflammatory-Related Events Versus Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis

Daniel A. Duprez, James Otvos, Russell P. Tracy, Kenneth R. Feingold, Philip Greenland, Myron D. Gross, Joao A. C. Lima, Rachel H. Mackey, James D. Neaton, Otto A. Sanchez, David R. Jacobs

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

BACKGROUND: High-density lipoprotein (HDL) particles have properties beyond reverse cholesterol transport. We hypothesized that their protection extends to inflammation-related disease. The predictive value of HDL particle subclasses and inflammatory markers was studied for noncardiovascular, noncancer chronic inflammation-related death and hospitalization, and for incident cardiovascular disease (CVD). METHODS AND RESULTS: A multiethnic, multicenter, prospective observational study was conducted in 6475 men and women (aged 45 to 84 years) free of known CVD at baseline with median follow-up of 10.1 years. Fasting venous samples were analyzed for baseline lipid profile and lipoprotein particles. We focused on the HDL family of variables (small-, medium-, and large-diameter HDL particles and HDL cholesterol). Analyses identified the sum of small- plus medium-diameter HDL particles as important. Small- plus medium-diameter HDL particles were inversely associated with diagnostic code-based noncardiovascular, noncancer chronic inflammation-related death and hospitalization (n=1054) independent of covariates: relative risk per SD 0.85 (95% CI: 0.79 to 0.91, P
Original languageEnglish (US)
JournalJournal of the American Heart Association
Volume4
Issue number9
DOIs
StatePublished - 2015

Keywords

  • cardiovascular events
  • high‐density lipoprotein
  • lipoprotein particles
  • Multi‐Ethnic Study of Atherosclerosis
  • noncardiovascular, noncancer chronic inflammation–related death and hospitalization

PubMed: MeSH publication types

  • Journal Article
  • Multicenter Study
  • Observational Study
  • Research Support, N.I.H., Extramural

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