Abstract
There is considerable evidence that antagonism of the endogenous opioids will suppress food intake in a variety of animal species. The authors report a double-blind, placebocontrolled trial of the long-acting, orally active narcotic antagonist naltrexone in the promotion of weight loss in obese male subjects who were also undergoing dietary counseling for weight reduction. Subjects received medication (naltrexone, 300 mg/day or placebo) for 8 weeks following an initial 2-week single-blind placebo phase. The results failed to demonstrate an advantage for the active drug. However, the naltrexone was associated with hepatotoxicity when used at this dosage in this population.
Original language | English (US) |
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Pages (from-to) | 35-42 |
Number of pages | 8 |
Journal | Biological Psychiatry |
Volume | 22 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1987 |