High-frequency ultrasonic atomization for drug delivery to rodent animal models - Optimal particle size for lung inhalation of difluoromethyl ornithine

Guifang Zhang; Chris Fandrey; Amir Naqwi; Timothy Scott Wiedmann

doi:10.1080/01902140802022484

High-frequency ultrasonic atomization for drug delivery to rodent animal models - Optimal particle size for lung inhalation of difluoromethyl ornithine

Guifang Zhang, Chris Fandrey, Amir Naqwi, Timothy Scott Wiedmann

Pharmaceutics

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A high-(8-MHz) and a low-(1.7-MHz) frequency ultrasonic transducer were compared for delivering aerosols to mouse lung. The aerosol concentration (mass of dry particles/volume of air) rose nonlinearly with solution concentration of difluoromethyl ornithine for both transducers. The particle size was linear with the cube root of the solution concentration, and the slope of the low-frequency transducer was 8 times greater than that of the high-frequency transducer. The deposition fraction assessed by the assayed mass in the lung relative to the calculated inhaled mass was found to decline exponentially with particle size. The lower-frequency transducer provided a higher dose despite a lower deposition fraction, but the high-frequency transducer was more efficient and provides a more selective deposition in the lower respiratory tract while operating with significantly less demands on aerosol drying.

Original language	English (US)
Pages (from-to)	209-223
Number of pages	15
Journal	Experimental Lung Research
Volume	34
Issue number	5
DOIs	https://doi.org/10.1080/01902140802022484
State	Published - Jun 2008

Bibliographical note

Funding Information:
Accepted 17 January 2007. Support was provided in part by NIH SBIR grant 1R43HL081789-01 (Program Official: Thomas Croxton) and NIH grant P01CA096964. Address correspondence to Timothy Scott Wiedmann, PhD, Department of Pharmaceutics, University of Minnesota, 308 Harvard Street SE, Minneapolis, MN 55455, USA. E-mail: wiedm001@umn.edu

Keywords

Aerosol delivery
Chemoprevention
DFMO
Output
Particle size distribution
Ultrasonic atomization

Access

10.1080/01902140802022484

OpenUrl availability

Full text

Cite this

@article{864cf7df60454240bbb1d55161c3549f,

title = "High-frequency ultrasonic atomization for drug delivery to rodent animal models - Optimal particle size for lung inhalation of difluoromethyl ornithine",

abstract = "A high-(8-MHz) and a low-(1.7-MHz) frequency ultrasonic transducer were compared for delivering aerosols to mouse lung. The aerosol concentration (mass of dry particles/volume of air) rose nonlinearly with solution concentration of difluoromethyl ornithine for both transducers. The particle size was linear with the cube root of the solution concentration, and the slope of the low-frequency transducer was 8 times greater than that of the high-frequency transducer. The deposition fraction assessed by the assayed mass in the lung relative to the calculated inhaled mass was found to decline exponentially with particle size. The lower-frequency transducer provided a higher dose despite a lower deposition fraction, but the high-frequency transducer was more efficient and provides a more selective deposition in the lower respiratory tract while operating with significantly less demands on aerosol drying.",

keywords = "Aerosol delivery, Chemoprevention, DFMO, Output, Particle size distribution, Ultrasonic atomization",

author = "Guifang Zhang and Chris Fandrey and Amir Naqwi and Wiedmann, {Timothy Scott}",

note = "Funding Information: Accepted 17 January 2007. Support was provided in part by NIH SBIR grant 1R43HL081789-01 (Program Official: Thomas Croxton) and NIH grant P01CA096964. Address correspondence to Timothy Scott Wiedmann, PhD, Department of Pharmaceutics, University of Minnesota, 308 Harvard Street SE, Minneapolis, MN 55455, USA. E-mail: wiedm001@umn.edu",

year = "2008",

month = jun,

doi = "10.1080/01902140802022484",

language = "English (US)",

volume = "34",

pages = "209--223",

journal = "Experimental Lung Research",

issn = "0190-2148",

publisher = "Informa Healthcare",

number = "5",

}

TY - JOUR

T1 - High-frequency ultrasonic atomization for drug delivery to rodent animal models - Optimal particle size for lung inhalation of difluoromethyl ornithine

AU - Zhang, Guifang

AU - Fandrey, Chris

AU - Naqwi, Amir

AU - Wiedmann, Timothy Scott

N1 - Funding Information: Accepted 17 January 2007. Support was provided in part by NIH SBIR grant 1R43HL081789-01 (Program Official: Thomas Croxton) and NIH grant P01CA096964. Address correspondence to Timothy Scott Wiedmann, PhD, Department of Pharmaceutics, University of Minnesota, 308 Harvard Street SE, Minneapolis, MN 55455, USA. E-mail: wiedm001@umn.edu

PY - 2008/6

Y1 - 2008/6

N2 - A high-(8-MHz) and a low-(1.7-MHz) frequency ultrasonic transducer were compared for delivering aerosols to mouse lung. The aerosol concentration (mass of dry particles/volume of air) rose nonlinearly with solution concentration of difluoromethyl ornithine for both transducers. The particle size was linear with the cube root of the solution concentration, and the slope of the low-frequency transducer was 8 times greater than that of the high-frequency transducer. The deposition fraction assessed by the assayed mass in the lung relative to the calculated inhaled mass was found to decline exponentially with particle size. The lower-frequency transducer provided a higher dose despite a lower deposition fraction, but the high-frequency transducer was more efficient and provides a more selective deposition in the lower respiratory tract while operating with significantly less demands on aerosol drying.

AB - A high-(8-MHz) and a low-(1.7-MHz) frequency ultrasonic transducer were compared for delivering aerosols to mouse lung. The aerosol concentration (mass of dry particles/volume of air) rose nonlinearly with solution concentration of difluoromethyl ornithine for both transducers. The particle size was linear with the cube root of the solution concentration, and the slope of the low-frequency transducer was 8 times greater than that of the high-frequency transducer. The deposition fraction assessed by the assayed mass in the lung relative to the calculated inhaled mass was found to decline exponentially with particle size. The lower-frequency transducer provided a higher dose despite a lower deposition fraction, but the high-frequency transducer was more efficient and provides a more selective deposition in the lower respiratory tract while operating with significantly less demands on aerosol drying.

KW - Aerosol delivery

KW - Chemoprevention

KW - DFMO

KW - Output

KW - Particle size distribution

KW - Ultrasonic atomization

UR - http://www.scopus.com/inward/record.url?scp=45849124682&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=45849124682&partnerID=8YFLogxK

U2 - 10.1080/01902140802022484

DO - 10.1080/01902140802022484

M3 - Article

C2 - 18465401

AN - SCOPUS:45849124682

SN - 0190-2148

VL - 34

SP - 209

EP - 223

JO - Experimental Lung Research

JF - Experimental Lung Research

IS - 5

ER -

High-frequency ultrasonic atomization for drug delivery to rodent animal models - Optimal particle size for lung inhalation of difluoromethyl ornithine

Abstract

Bibliographical note

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this