High level of plasma endothelin-1 predicts development of hypertension in normotensive subjects

Shun Ichi Kumagae; Hisashi Adachi; David R. Jacobs; Yuji Hirai; Mika Enomoto; Ako Fukami; Maki Otsuka; Yasuki Nanjo; Eishi Esaki; Eita Kumagai; Kuniko Yoshikawa; Kanako Yokoi; Kinuka Ogata; Eri Tsukagawa; Akiko Kasahara; Kyoko Murayama; Tsutomu Imaizumi

doi:10.1038/ajh.2010.125

High level of plasma endothelin-1 predicts development of hypertension in normotensive subjects

Shun Ichi Kumagae, Hisashi Adachi, David R. Jacobs, Yuji Hirai, Mika Enomoto, Ako Fukami, Maki Otsuka, Yasuki Nanjo, Eishi Esaki, Eita Kumagai, Kuniko Yoshikawa, Kanako Yokoi, Kinuka Ogata, Eri Tsukagawa, Akiko Kasahara, Kyoko Murayama, Tsutomu Imaizumi

Epidemiology

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14 Scopus citations

Abstract

Background: Endothelin-1 (ET-1) is a potent vasoconstrictor derived from the endothelium. However, most large scale cross-sectional studies in humans have indicated no relationship between plasma ET-1 levels and hypertension. The present study was designed to determine whether high plasma ET-1 levels predict the development of hypertension.MethodsA total of 1,492 subjects received a health examination in the Japanese cohort of Seven Countries Study in 1999, when, we examined blood pressure (BP), body mass index (BMI), and blood chemistries. Data on fasting ET-1 were obtained from 1,451 individuals. Seven years later, 1,261 subjects (494 males and 767 females) were re-examined (follow-up rate = 87%).ResultsOf 814 normotensives (BP 140/90mmHg without antihypertensive medications) at baseline, 222 subjects developed hypertension. We divided the baseline plasma ET-1 levels into quartiles. The odds ratio for the development of hypertension after 7 years was 1.79 (95% confidence interval (CI): 1.08-2.96) in the highest quartile vs. the lowest quartile of ET-1 level after adjustment for confounding factors.ConclusionA high level of plasma ET-1 predicted the development of hypertension in normotensive subjects.

Original language	English (US)
Pages (from-to)	1103-1107
Number of pages	5
Journal	American journal of hypertension
Volume	23
Issue number	10
DOIs	https://doi.org/10.1038/ajh.2010.125
State	Published - Oct 27 2010

Bibliographical note

Funding Information:
Acknowledgments: We are grateful to the members of the Japan Medical Association of Ukiha, the elected officials and residents ofTanushimaru, and the team of cooperating physicians for their help in performing the health examinations.This study was supported in part by the Kimura Memorial Heart Foundation (Fukuoka, Japan).

Keywords

Seven Countries Study
Tanushimaru
blood pressure
endothelium
epidemiology
hypertension
prospective study

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Kumagae, S. I., Adachi, H., Jacobs, D. R., Hirai, Y., Enomoto, M., Fukami, A., Otsuka, M., Nanjo, Y., Esaki, E., Kumagai, E., Yoshikawa, K., Yokoi, K., Ogata, K., Tsukagawa, E., Kasahara, A., Murayama, K., & Imaizumi, T. (2010). High level of plasma endothelin-1 predicts development of hypertension in normotensive subjects. American journal of hypertension, 23(10), 1103-1107. https://doi.org/10.1038/ajh.2010.125

Kumagae, SI, Adachi, H, Jacobs, DR, Hirai, Y, Enomoto, M, Fukami, A, Otsuka, M, Nanjo, Y, Esaki, E, Kumagai, E, Yoshikawa, K, Yokoi, K, Ogata, K, Tsukagawa, E, Kasahara, A, Murayama, K & Imaizumi, T 2010, 'High level of plasma endothelin-1 predicts development of hypertension in normotensive subjects', American journal of hypertension, vol. 23, no. 10, pp. 1103-1107. https://doi.org/10.1038/ajh.2010.125

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abstract = "Background: Endothelin-1 (ET-1) is a potent vasoconstrictor derived from the endothelium. However, most large scale cross-sectional studies in humans have indicated no relationship between plasma ET-1 levels and hypertension. The present study was designed to determine whether high plasma ET-1 levels predict the development of hypertension.MethodsA total of 1,492 subjects received a health examination in the Japanese cohort of Seven Countries Study in 1999, when, we examined blood pressure (BP), body mass index (BMI), and blood chemistries. Data on fasting ET-1 were obtained from 1,451 individuals. Seven years later, 1,261 subjects (494 males and 767 females) were re-examined (follow-up rate = 87%).ResultsOf 814 normotensives (BP 140/90mmHg without antihypertensive medications) at baseline, 222 subjects developed hypertension. We divided the baseline plasma ET-1 levels into quartiles. The odds ratio for the development of hypertension after 7 years was 1.79 (95% confidence interval (CI): 1.08-2.96) in the highest quartile vs. the lowest quartile of ET-1 level after adjustment for confounding factors.ConclusionA high level of plasma ET-1 predicted the development of hypertension in normotensive subjects.",

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author = "Kumagae, {Shun Ichi} and Hisashi Adachi and Jacobs, {David R.} and Yuji Hirai and Mika Enomoto and Ako Fukami and Maki Otsuka and Yasuki Nanjo and Eishi Esaki and Eita Kumagai and Kuniko Yoshikawa and Kanako Yokoi and Kinuka Ogata and Eri Tsukagawa and Akiko Kasahara and Kyoko Murayama and Tsutomu Imaizumi",

note = "Funding Information: Acknowledgments: We are grateful to the members of the Japan Medical Association of Ukiha, the elected officials and residents ofTanushimaru, and the team of cooperating physicians for their help in performing the health examinations.This study was supported in part by the Kimura Memorial Heart Foundation (Fukuoka, Japan).",

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AU - Adachi, Hisashi

AU - Jacobs, David R.

AU - Hirai, Yuji

AU - Enomoto, Mika

AU - Fukami, Ako

AU - Otsuka, Maki

AU - Nanjo, Yasuki

AU - Esaki, Eishi

AU - Kumagai, Eita

AU - Yoshikawa, Kuniko

AU - Yokoi, Kanako

AU - Ogata, Kinuka

AU - Tsukagawa, Eri

AU - Kasahara, Akiko

AU - Murayama, Kyoko

AU - Imaizumi, Tsutomu

N1 - Funding Information: Acknowledgments: We are grateful to the members of the Japan Medical Association of Ukiha, the elected officials and residents ofTanushimaru, and the team of cooperating physicians for their help in performing the health examinations.This study was supported in part by the Kimura Memorial Heart Foundation (Fukuoka, Japan).

PY - 2010/10/27

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N2 - Background: Endothelin-1 (ET-1) is a potent vasoconstrictor derived from the endothelium. However, most large scale cross-sectional studies in humans have indicated no relationship between plasma ET-1 levels and hypertension. The present study was designed to determine whether high plasma ET-1 levels predict the development of hypertension.MethodsA total of 1,492 subjects received a health examination in the Japanese cohort of Seven Countries Study in 1999, when, we examined blood pressure (BP), body mass index (BMI), and blood chemistries. Data on fasting ET-1 were obtained from 1,451 individuals. Seven years later, 1,261 subjects (494 males and 767 females) were re-examined (follow-up rate = 87%).ResultsOf 814 normotensives (BP 140/90mmHg without antihypertensive medications) at baseline, 222 subjects developed hypertension. We divided the baseline plasma ET-1 levels into quartiles. The odds ratio for the development of hypertension after 7 years was 1.79 (95% confidence interval (CI): 1.08-2.96) in the highest quartile vs. the lowest quartile of ET-1 level after adjustment for confounding factors.ConclusionA high level of plasma ET-1 predicted the development of hypertension in normotensive subjects.

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High level of plasma endothelin-1 predicts development of hypertension in normotensive subjects

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