TY - JOUR
T1 - 'High-Load' Polyethylene glycol-Polystyrene (PEG-PS) graft supports for solid-phase synthesis
AU - Kates, Steven A.
AU - McGuinness, Brian F.
AU - Blackburn, Christopher
AU - Griffin, G. William
AU - Solé, Nuriá A.
AU - Barany, George
AU - Albericio, Fernando
PY - 1998
Y1 - 1998
N2 - The choice of a polymeric support is a key factor for the success of solid-phase methods for syntheses of organic compounds and biomolecules such as peptides and oligonucleotides. Classical Merrifield solid-phase peptide synthesis (SPPS), performed on low cross-linked hydro-phobic polystyrene (PS) beads, sometimes suffers from sequence-dependent coupling difficulties. The concept of incorporating polyethylene glycol (PEG) into supports for solid- phase synthesis represents a successful approach to alleviating such problems. Previous reports from our laboratories have shown the advantages of 'low-load' PEG-PS(0.15-0.25 mmol/g) for SPPS. Herein, we demonstrate that the beneficial aspects of the PEG-PS concept can be extended with resins that have higher loadings (0.3-0.5 mmol/g).
AB - The choice of a polymeric support is a key factor for the success of solid-phase methods for syntheses of organic compounds and biomolecules such as peptides and oligonucleotides. Classical Merrifield solid-phase peptide synthesis (SPPS), performed on low cross-linked hydro-phobic polystyrene (PS) beads, sometimes suffers from sequence-dependent coupling difficulties. The concept of incorporating polyethylene glycol (PEG) into supports for solid- phase synthesis represents a successful approach to alleviating such problems. Previous reports from our laboratories have shown the advantages of 'low-load' PEG-PS(0.15-0.25 mmol/g) for SPPS. Herein, we demonstrate that the beneficial aspects of the PEG-PS concept can be extended with resins that have higher loadings (0.3-0.5 mmol/g).
KW - Chemical libraries
KW - Polyethylene glycol-polystyrene (PEG- PS)
KW - Polymeric supports
KW - Solid-phase combinatorial chemistry
KW - Solid-phase peptide synthesis
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U2 - 10.1002/(SICI)1097-0282(1998)47:5<365::AID-BIP4>3.0.CO;2-8
DO - 10.1002/(SICI)1097-0282(1998)47:5<365::AID-BIP4>3.0.CO;2-8
M3 - Article
C2 - 9973867
AN - SCOPUS:0032461335
SN - 0006-3525
VL - 47
SP - 365
EP - 380
JO - Biopolymers - Peptide Science Section
JF - Biopolymers - Peptide Science Section
IS - 5
ER -