Abstract
Following the 2017 European LeukemiaNet (ELN) guidelines, we changed our practice from using high-dose cytarabine (HIDAC-3 g/m2 q12h-D1,3,5) to intermediate-dose cytarabine (IDAC-1·5 g/m2 q12h-D1,3,5/D1–3) for consolidation in young(<60 years) favourable-risk acute myeloid leukaemia (AML) patients. We assessed the clinical impact of this practice change. Of 80 patients, 51 received HIDAC prior to the protocol change, and subsequently, 29 received IDAC. The three-year risk of relapse was significantly higher with IDAC [61%; 95% confidence interval (CI) 40–82] compared with HIDAC (22%; 10–34), P < 0·01. Our findings suggest HIDAC, rather than IDAC, is the preferred dose for single-agent cytarabine consolidation in young, favourable-risk AML following 7+3 induction.
Original language | English (US) |
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Pages (from-to) | 140-144 |
Number of pages | 5 |
Journal | British journal of haematology |
Volume | 194 |
Issue number | 1 |
DOIs | |
State | Published - Jul 2021 |
Bibliographical note
Funding Information:None of the authors received funding support for the conduct of this study. Support received outside of this study: DW received research support from FATE therapeutics and Incyte; ZL received NMRC research training fellowship, speaker fees from Astellas and Amgen, honoraria from Astellas, Amgen and Novartis; ZS received research reagents from Jazz pharmaceuticals, research funds and reagents from Stemline therapeutics; FH received consultant fees from Abbvie and Magenta therapeutics.
Publisher Copyright:
© 2021 British Society for Haematology and John Wiley & Sons Ltd
Keywords
- acute leukaemia
- chemotherapy
- consolidation
PubMed: MeSH publication types
- Comparative Study
- Journal Article
- Multicenter Study
- Review