High-throughput microfluidic chip for automated in vitro release testing

M. Alberti; Y. Dancik; B. Wu; Z. Feng; R. G. Wu; M. Bigliardi-Qi; P. L. Bigliardi; Z. P. Wang

High-throughput microfluidic chip for automated in vitro release testing

M. Alberti, Y. Dancik, B. Wu, Z. Feng, R. G. Wu, M. Bigliardi-Qi, P. L. Bigliardi, Z. P. Wang

Dermatology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A multiple chamber microfluidic system for in vitro release and skin permeability testing has been developed. Infinite dose permeation studies with salicylic acid (SA) applied on silicone membranes were run in the microfluidic chip and in six Franz diffusion cells. The diffusion profiles are comparable in the two systems, however the steady state flux measured in the chip is 35% higher. Due to the small volumes and the continuous flow in the microfluidic chambers, the chip enables more accurate permeation profiles with coefficients of variations (CV) below 5% at steady state.

Original language	English (US)
Title of host publication	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Publisher	Chemical and Biological Microsystems Society
Pages	589-590
Number of pages	2
ISBN (Electronic)	9780979806490
State	Published - 2016
Event	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland Duration: Oct 9 2016 → Oct 13 2016

Publication series

Name	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

Other

Other	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Country/Territory	Ireland
City	Dublin
Period	10/9/16 → 10/13/16

Bibliographical note

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

High-throughput
In vitro release
Skin permeability
Skin-on-a-chip

OpenUrl availability

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Cite this

Alberti, M., Dancik, Y., Wu, B., Feng, Z., Wu, R. G., Bigliardi-Qi, M., Bigliardi, P. L., & Wang, Z. P. (2016). High-throughput microfluidic chip for automated in vitro release testing. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 (pp. 589-590). (20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016). Chemical and Biological Microsystems Society.

High-throughput microfluidic chip for automated in vitro release testing. / Alberti, M.; Dancik, Y.; Wu, B. et al.
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, 2016. p. 589-590 (20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Alberti, M, Dancik, Y, Wu, B, Feng, Z, Wu, RG, Bigliardi-Qi, M , Bigliardi, PL & Wang, ZP 2016, High-throughput microfluidic chip for automated in vitro release testing. in 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, Chemical and Biological Microsystems Society, pp. 589-590, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, Dublin, Ireland, 10/9/16.

Alberti M, Dancik Y, Wu B, Feng Z, Wu RG, Bigliardi-Qi M et al. High-throughput microfluidic chip for automated in vitro release testing. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society. 2016. p. 589-590. (20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016).

Alberti, M. ; Dancik, Y. ; Wu, B. et al. / High-throughput microfluidic chip for automated in vitro release testing. 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, 2016. pp. 589-590 (20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016).

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AU - Bigliardi, P. L.

AU - Wang, Z. P.

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KW - Skin permeability

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BT - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

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ER -

High-throughput microfluidic chip for automated in vitro release testing

Abstract

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Keywords

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