Highly diastereoselective one-pot four-component coupling of p-TolSCl, 1-methoxycycloalkene, methyl vinyl ether and a carbon nucleophile leading to the synthesis of polyfunctional compounds

Margarita I. Lazareva, Yury K. Kryschenko, Ron Caple, Victor G Young, William A. Smit

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

An one-pot TiCl4 initiated assemblage of polyfunctional compounds via a sequential coupling of p-TolSCl, 1-methoxycycloalkene, methyl vinyl ether and Sn-or Si-capped carbon nucleophile is shown to proceed with high diastereoselectivity at all newly created chiral centres.

Original languageEnglish (US)
Pages (from-to)24-25
Number of pages2
JournalMendeleev Communications
Volume9
Issue number1
DOIs
StatePublished - 1999

Bibliographical note

Funding Information:
This work was supported by the National Science Foundation (grant no. 8921358), the U.S. Civilian Research and Development Foundation (award no. RC2-141) and the Russian Foundation for Basic Research (grant no. 98-03-32970a).

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

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