An one-pot TiCl4 initiated assemblage of polyfunctional compounds via a sequential coupling of p-TolSCl, 1-methoxycycloalkene, methyl vinyl ether and Sn-or Si-capped carbon nucleophile is shown to proceed with high diastereoselectivity at all newly created chiral centres.
Bibliographical noteFunding Information:
This work was supported by the National Science Foundation (grant no. 8921358), the U.S. Civilian Research and Development Foundation (award no. RC2-141) and the Russian Foundation for Basic Research (grant no. 98-03-32970a).
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