TY - JOUR
T1 - Hippocampal deafferentation
T2 - transplant‐derived reinnervation and functional recovery
AU - DUNNETT, S. B.
AU - GAGE, F. H.
AU - BJÖRKLUND, A.
AU - STENEVI, U.
AU - LOW, W. C.
AU - IVERSEN, S. D.
PY - 1984/8
Y1 - 1984/8
N2 - A brief review is provided of the capacity of neural tissue transplants to reinnervate the deafferented hippocampus and repair functional deficits induced by the lesion. The techniques for transplantation of solid pieces of embryonic septum, locus coeruleus or raphe nuclei, or tissue suspensions of embryonic septum, to the adult rat hippocampus are described. Such grafts manifest good long‐term survival. provide a good reinnervation of the hippocampus that is histochemically and biochemically appropriate and specific, can establish ultrastructural synaptic contacts with the host, and are electrophysiologically active. Rats with septal grafts manifest recovery of the capacity to learn certain aspects of radial 8‐arm maze, T‐maze alternation and Morris water‐maze tasks. Rats with locus coeruleus grafts manifest an amelioration of lesion‐induced hyperactivity. It is concluded that neural tissue transplantation provides a powerful new tool in the study of the functional organization of the hippocampus and its various neurotransmitter‐specific afferent systems.
AB - A brief review is provided of the capacity of neural tissue transplants to reinnervate the deafferented hippocampus and repair functional deficits induced by the lesion. The techniques for transplantation of solid pieces of embryonic septum, locus coeruleus or raphe nuclei, or tissue suspensions of embryonic septum, to the adult rat hippocampus are described. Such grafts manifest good long‐term survival. provide a good reinnervation of the hippocampus that is histochemically and biochemically appropriate and specific, can establish ultrastructural synaptic contacts with the host, and are electrophysiologically active. Rats with septal grafts manifest recovery of the capacity to learn certain aspects of radial 8‐arm maze, T‐maze alternation and Morris water‐maze tasks. Rats with locus coeruleus grafts manifest an amelioration of lesion‐induced hyperactivity. It is concluded that neural tissue transplantation provides a powerful new tool in the study of the functional organization of the hippocampus and its various neurotransmitter‐specific afferent systems.
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U2 - 10.1111/j.1600-0447.1984.tb07153.x
DO - 10.1111/j.1600-0447.1984.tb07153.x
M3 - Article
C2 - 6322523
AN - SCOPUS:84995248788
SN - 0001-690X
VL - 70
SP - 46
EP - 56
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
ER -