Hippocampal deafferentation: transplant‐derived reinnervation and functional recovery

S. B. DUNNETT, F. H. GAGE, A. BJÖRKLUND, U. STENEVI, W. C. LOW, S. D. IVERSEN

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A brief review is provided of the capacity of neural tissue transplants to reinnervate the deafferented hippocampus and repair functional deficits induced by the lesion. The techniques for transplantation of solid pieces of embryonic septum, locus coeruleus or raphe nuclei, or tissue suspensions of embryonic septum, to the adult rat hippocampus are described. Such grafts manifest good long‐term survival. provide a good reinnervation of the hippocampus that is histochemically and biochemically appropriate and specific, can establish ultrastructural synaptic contacts with the host, and are electrophysiologically active. Rats with septal grafts manifest recovery of the capacity to learn certain aspects of radial 8‐arm maze, T‐maze alternation and Morris water‐maze tasks. Rats with locus coeruleus grafts manifest an amelioration of lesion‐induced hyperactivity. It is concluded that neural tissue transplantation provides a powerful new tool in the study of the functional organization of the hippocampus and its various neurotransmitter‐specific afferent systems.

Original languageEnglish (US)
Pages (from-to)46-56
Number of pages11
JournalActa Psychiatrica Scandinavica
Volume70
DOIs
StatePublished - Aug 1984

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