Hippocampal subfield abnormalities and memory functioning in children with fetal alcohol Spectrum disorders

Donovan J. Roediger, Alyssa M. Krueger, Erik de Water, Bryon A. Mueller, Christopher A. Boys, Timothy J. Hendrickson, Mariah J. Schumacher, Sarah N. Mattson, Kenneth L. Jones, Kelvin O. Lim, Jeffrey R. Wozniak

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Prenatal alcohol exposure (PAE) affects early brain development and has been associated with hippocampal damage. Animal models of PAE have suggested that some subfields of the hippocampus may be more susceptible to damage than others. Recent advances in structural MRI processing now allow us to examine the morphology of hippocampal subfields in humans with PAE. Method: Structural MRI scans were collected from 40 children with PAE and 39 typically developing children (ages 8–16). The images were processed using the Human Connectome Project Minimal Preprocessing Pipeline (v4.0.1) and the Hippocampal Subfields package (v21) from FreeSurfer. Using a large dataset of typically developing children enrolled in the Human Connectome Project in Development (HCP-D) for normative standards, we computed age-specific volumetric z-scores for our two samples. Using these norm-adjusted hippocampal subfield volumes, comparisons were performed between children with PAE and typically developing children, controlling for total intracranial volume. Lastly, we investigated whether subfield volumes correlated with episodic memory (i.e., Picture Sequence Memory test of the NIH toolbox). Results: Five subfields had significantly smaller adjusted volumes in children with PAE than in typically developing controls: CA1, CA4, subiculum, presubiculum, and the hippocampal tail. Subfield volumes were not significantly correlated with episodic memory. Conclusions: The results suggest that several regions of the hippocampus may be particularly affected by PAE. The finding of smaller CA1 volumes parallels previous reports in rodent models. The novel findings of decreased volume in the subicular cortex, CA4 and the hippocampal tail suggest avenues for future research.

Original languageEnglish (US)
Article number106944
JournalNeurotoxicology and Teratology
Volume83
DOIs
StatePublished - Jan 1 2021

Bibliographical note

Funding Information:
This work was done in conjunction with the Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD), which is funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Additional information about CIFASD can be found at www.cifasd.org . Support for this project was provided by the NIAAA ( 5U01AA026102 , 5U01AA014834 , 5U24AA014815 , 5U24AA014811 ), the National Institute of Biomedical Imaging and Bioengineering ( NIBIB P41 EB027061 ), the Biotechnology Research Center ( P41 EB015 894 ), the NINDS Institutional Center Core Grants to Support Neuroscience Research ( P30 NS076408 ), and the High Performance Connectome Upgrade for Human 3T MR Scanner ( 1S10OD017974-01 ).

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

  • Brain
  • Hippocampus
  • MRI
  • Memory
  • Prenatal alcohol exposure

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural

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