Histopathologic and Trypsin Digestion Studies of the Retina in Incontinentia Pigmenti

W. Robert Bell, W. Richard Green, Morton F. Goldberg

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Objective: To report the ocular histopathologic features of a 55-year-old patient with incontinentia pigmenti retinopathy. Design: Observational case report. Participant: A 55-year-old patient with incontinentia pigmenti retinopathy. Methods: Examination of eyes by light microscopy and retinal trypsin digestion. Main Outcome Measures: Clinical and histopathological findings. Results: Histopathologic examination disclosed inner retinal ischemic atrophy, capillary beading, arteriolar-venous anastomoses, preretinal neovascularization, vasculopathy located at the junction of central vascular and peripheral avascular retina, retinal tears, and tractional retinoschisis. Conclusions: Patients with retinal manifestations of incontinentia pigmenti may progress to proliferative vitreoretinopathy or retinal detachment and should be observed closely over the course of their lifetime.

Original languageEnglish (US)
Pages (from-to)893-897
Number of pages5
JournalOphthalmology
Volume115
Issue number5
DOIs
StatePublished - May 2008

Bibliographical note

Funding Information:
Supported in part by Independent Order of Odd Fellows, Winston-Salem, North Carolina (WRG), and the Guerrieri Retinal Research Fund at the Wilmer Eye Institute (MFG).

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

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