HIV serostatus differs by catechol-O-methyltransferase Val158Met genotype

Erin E. Sundermann; Jeffrey R. Bishop; Leah H. Rubin; Bradley Aouizerat; Tracey E. Wilson; Kathleen M. Weber; Mardge Cohen; Elizabeth Golub; Kathryn Anastos; Chenglong Liu; Howard Crystal; Celeste L. Pearce; Pauline M. Maki

doi:10.1097/QAD.0b013e328361c6a1

HIV serostatus differs by catechol-O-methyltransferase Val158Met genotype

Erin E. Sundermann, Jeffrey R. Bishop, Leah H. Rubin, Bradley Aouizerat, Tracey E. Wilson, Kathleen M. Weber, Mardge Cohen, Elizabeth Golub, Kathryn Anastos, Chenglong Liu, Howard Crystal, Celeste L. Pearce, Pauline M. Maki

Experimental and Clinical Pharmacology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

OBJECTIVE: The Met allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with increased cortical dopamine and risk behaviors including illicit drug use and unprotected sex. Therefore, we examined whether or not the distribution of the Val158Met genotype differed between HIV-infected and HIV-uninfected women. DESIGN: Cross-sectional analysis using data from the Women's Interagency HIV Study (WIHS), the largest longitudinal cohort study of HIV in women. METHODS: We conducted an Armitage-Cochran test and logistic regression to compare genotype frequencies between 1848 HIV-infected and 612 HIV-uninfected women in WIHS. RESULTS: The likelihood of carrying one or two Met alleles was greater in HIV-infected women (61%) compared to HIV-uninfected women (54%), Zâ€Š=â€Š-3.60, Pâ€Š<0.001. CONCLUSION: We report the novel finding of an association between the Val158Met genotype and HIV serostatus that may be mediated through the impact of dopamine function on propensity for risk-taking.

Original language	English (US)
Pages (from-to)	1779-1782
Number of pages	4
Journal	AIDS
Volume	27
Issue number	11
DOIs	https://doi.org/10.1097/QAD.0b013e328361c6a1
State	Published - Jul 17 2013

Keywords

COMT genotype
HIV risk
Val158Met
dopamine
risk behavior

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title = "HIV serostatus differs by catechol-O-methyltransferase Val158Met genotype",

abstract = "OBJECTIVE: The Met allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with increased cortical dopamine and risk behaviors including illicit drug use and unprotected sex. Therefore, we examined whether or not the distribution of the Val158Met genotype differed between HIV-infected and HIV-uninfected women. DESIGN: Cross-sectional analysis using data from the Women's Interagency HIV Study (WIHS), the largest longitudinal cohort study of HIV in women. METHODS: We conducted an Armitage-Cochran test and logistic regression to compare genotype frequencies between 1848 HIV-infected and 612 HIV-uninfected women in WIHS. RESULTS: The likelihood of carrying one or two Met alleles was greater in HIV-infected women (61%) compared to HIV-uninfected women (54%), Z{\^a}€{\v S}={\^a}€{\v S}-3.60, P{\^a}€{\v S}<0.001. CONCLUSION: We report the novel finding of an association between the Val158Met genotype and HIV serostatus that may be mediated through the impact of dopamine function on propensity for risk-taking.",

keywords = "COMT genotype, HIV risk, Val158Met, dopamine, risk behavior",

author = "Sundermann, {Erin E.} and Bishop, {Jeffrey R.} and Rubin, {Leah H.} and Bradley Aouizerat and Wilson, {Tracey E.} and Weber, {Kathleen M.} and Mardge Cohen and Elizabeth Golub and Kathryn Anastos and Chenglong Liu and Howard Crystal and Pearce, {Celeste L.} and Maki, {Pauline M.}",

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TY - JOUR

T1 - HIV serostatus differs by catechol-O-methyltransferase Val158Met genotype

AU - Sundermann, Erin E.

AU - Bishop, Jeffrey R.

AU - Rubin, Leah H.

AU - Aouizerat, Bradley

AU - Wilson, Tracey E.

AU - Weber, Kathleen M.

AU - Cohen, Mardge

AU - Golub, Elizabeth

AU - Anastos, Kathryn

AU - Liu, Chenglong

AU - Crystal, Howard

AU - Pearce, Celeste L.

AU - Maki, Pauline M.

PY - 2013/7/17

Y1 - 2013/7/17

N2 - OBJECTIVE: The Met allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with increased cortical dopamine and risk behaviors including illicit drug use and unprotected sex. Therefore, we examined whether or not the distribution of the Val158Met genotype differed between HIV-infected and HIV-uninfected women. DESIGN: Cross-sectional analysis using data from the Women's Interagency HIV Study (WIHS), the largest longitudinal cohort study of HIV in women. METHODS: We conducted an Armitage-Cochran test and logistic regression to compare genotype frequencies between 1848 HIV-infected and 612 HIV-uninfected women in WIHS. RESULTS: The likelihood of carrying one or two Met alleles was greater in HIV-infected women (61%) compared to HIV-uninfected women (54%), Zâ€Š=â€Š-3.60, Pâ€Š<0.001. CONCLUSION: We report the novel finding of an association between the Val158Met genotype and HIV serostatus that may be mediated through the impact of dopamine function on propensity for risk-taking.

AB - OBJECTIVE: The Met allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with increased cortical dopamine and risk behaviors including illicit drug use and unprotected sex. Therefore, we examined whether or not the distribution of the Val158Met genotype differed between HIV-infected and HIV-uninfected women. DESIGN: Cross-sectional analysis using data from the Women's Interagency HIV Study (WIHS), the largest longitudinal cohort study of HIV in women. METHODS: We conducted an Armitage-Cochran test and logistic regression to compare genotype frequencies between 1848 HIV-infected and 612 HIV-uninfected women in WIHS. RESULTS: The likelihood of carrying one or two Met alleles was greater in HIV-infected women (61%) compared to HIV-uninfected women (54%), Zâ€Š=â€Š-3.60, Pâ€Š<0.001. CONCLUSION: We report the novel finding of an association between the Val158Met genotype and HIV serostatus that may be mediated through the impact of dopamine function on propensity for risk-taking.

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KW - HIV risk

KW - Val158Met

KW - dopamine

KW - risk behavior

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ER -

HIV serostatus differs by catechol-O-methyltransferase Val158Met genotype

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