Hormonal and reproductive factors and risk of myeloproliferative neoplasms in postmenopausal women

Alexis D. Leal; Carrie A. Thompson; Alice H. Wang; Robert A. Vierkant; Thomas M. Habermann; Julie A. Ross; Ruben A. Mesa; Beth A. Virnig; James R. Cerhan

doi:10.1158/1055-9965.EPI-15-0613

Hormonal and reproductive factors and risk of myeloproliferative neoplasms in postmenopausal women

Alexis D. Leal, Carrie A. Thompson, Alice H. Wang, Robert A. Vierkant, Thomas M. Habermann, Julie A. Ross, Ruben A. Mesa, Beth A. Virnig, James R. Cerhan

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Abstract

Background: Hormonal and reproductive history has been associated with risk of some hematologic malignancies, but their role in myeloproliferative neoplasms (MPN) is largely unknown. Methods: Using a population-based cohort study, we evaluated the association of these factors with risk of MPN overall, and for essential thrombocythemia (ET) and polycythemia vera (PV) specifically. Incident MPN cases from 1993 to 2004 were identified via linkage to Medicare. RR and 95% confidence intervals (CI) were estimated utilizing Cox proportional hazard regression. Results: After >250,000 person-years of follow-up, 257 cases of MPN were identified (172 ET, 64 PV). Ever use of hormone therapy (HT) was associated with an increased risk of ET (RR = 1.63; 95% CI, 1.19-2.23) but a decreased risk of PV (RR = 0.58; 95% CI, 0.34-0.98). There were no statistically significant associations of oral contraceptives or reproductive factors with MPN risk overall, or by MPN subtype. Bilateral oophorectomy was associated with increased risk of ET (RR = 1.58; 95% CI, 1.11-2.25) and decreased risk of PV (RR = 0.32; 95% CI, 0.12-0.88). There was no association of ovulatory years with ET risk; however, there was increased risk of PV (RR = 1.68 for >36.8 compared with ≤27.6 years; P trend = 0.045). Adjustment for potential confounding factors did not alter these associations. Conclusions: HT use and bilateral oophorectomy had opposite associations for ET and PV. Except for ovulatory years and PV risk, reproductive history did not appear to play a role in the etiology of MPN. Impact: This study suggests different mechanistic impacts of estrogen, and perhaps distinct etiologies, for the two major MPN subtypes.

Original language	English (US)
Pages (from-to)	151-157
Number of pages	7
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	25
Issue number	1
DOIs	https://doi.org/10.1158/1055-9965.EPI-15-0613
State	Published - Jan 2016

Bibliographical note

Funding Information:
The authors wish to thank Sondra Buehler for editorial assistance. The authors also thank Drs. Aaron Folsom and DeAnn Lazovich, the former and current Principal Investigator of the IWHS study. This work was supported by grants from the NIH [R01 CA39742 (A.R. Folsom); K05 CA157439 (A.D. Leal)]. There are no financial disclosures to report.

Publisher Copyright:
©2015 AACR.

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@article{73ef53c43f66404c80631b50dd1188ba,

title = "Hormonal and reproductive factors and risk of myeloproliferative neoplasms in postmenopausal women",

abstract = "Background: Hormonal and reproductive history has been associated with risk of some hematologic malignancies, but their role in myeloproliferative neoplasms (MPN) is largely unknown. Methods: Using a population-based cohort study, we evaluated the association of these factors with risk of MPN overall, and for essential thrombocythemia (ET) and polycythemia vera (PV) specifically. Incident MPN cases from 1993 to 2004 were identified via linkage to Medicare. RR and 95% confidence intervals (CI) were estimated utilizing Cox proportional hazard regression. Results: After >250,000 person-years of follow-up, 257 cases of MPN were identified (172 ET, 64 PV). Ever use of hormone therapy (HT) was associated with an increased risk of ET (RR = 1.63; 95% CI, 1.19-2.23) but a decreased risk of PV (RR = 0.58; 95% CI, 0.34-0.98). There were no statistically significant associations of oral contraceptives or reproductive factors with MPN risk overall, or by MPN subtype. Bilateral oophorectomy was associated with increased risk of ET (RR = 1.58; 95% CI, 1.11-2.25) and decreased risk of PV (RR = 0.32; 95% CI, 0.12-0.88). There was no association of ovulatory years with ET risk; however, there was increased risk of PV (RR = 1.68 for >36.8 compared with ≤27.6 years; P trend = 0.045). Adjustment for potential confounding factors did not alter these associations. Conclusions: HT use and bilateral oophorectomy had opposite associations for ET and PV. Except for ovulatory years and PV risk, reproductive history did not appear to play a role in the etiology of MPN. Impact: This study suggests different mechanistic impacts of estrogen, and perhaps distinct etiologies, for the two major MPN subtypes.",

author = "Leal, {Alexis D.} and Thompson, {Carrie A.} and Wang, {Alice H.} and Vierkant, {Robert A.} and Habermann, {Thomas M.} and Ross, {Julie A.} and Mesa, {Ruben A.} and Virnig, {Beth A.} and Cerhan, {James R.}",

note = "Funding Information: The authors wish to thank Sondra Buehler for editorial assistance. The authors also thank Drs. Aaron Folsom and DeAnn Lazovich, the former and current Principal Investigator of the IWHS study. This work was supported by grants from the NIH [R01 CA39742 (A.R. Folsom); K05 CA157439 (A.D. Leal)]. There are no financial disclosures to report. Publisher Copyright: {\textcopyright}2015 AACR.",

year = "2016",

month = jan,

doi = "10.1158/1055-9965.EPI-15-0613",

language = "English (US)",

volume = "25",

pages = "151--157",

journal = "Cancer Epidemiology Biomarkers and Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

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T1 - Hormonal and reproductive factors and risk of myeloproliferative neoplasms in postmenopausal women

AU - Leal, Alexis D.

AU - Thompson, Carrie A.

AU - Wang, Alice H.

AU - Vierkant, Robert A.

AU - Habermann, Thomas M.

AU - Ross, Julie A.

AU - Mesa, Ruben A.

AU - Virnig, Beth A.

AU - Cerhan, James R.

N1 - Funding Information: The authors wish to thank Sondra Buehler for editorial assistance. The authors also thank Drs. Aaron Folsom and DeAnn Lazovich, the former and current Principal Investigator of the IWHS study. This work was supported by grants from the NIH [R01 CA39742 (A.R. Folsom); K05 CA157439 (A.D. Leal)]. There are no financial disclosures to report. Publisher Copyright: ©2015 AACR.

PY - 2016/1

Y1 - 2016/1

N2 - Background: Hormonal and reproductive history has been associated with risk of some hematologic malignancies, but their role in myeloproliferative neoplasms (MPN) is largely unknown. Methods: Using a population-based cohort study, we evaluated the association of these factors with risk of MPN overall, and for essential thrombocythemia (ET) and polycythemia vera (PV) specifically. Incident MPN cases from 1993 to 2004 were identified via linkage to Medicare. RR and 95% confidence intervals (CI) were estimated utilizing Cox proportional hazard regression. Results: After >250,000 person-years of follow-up, 257 cases of MPN were identified (172 ET, 64 PV). Ever use of hormone therapy (HT) was associated with an increased risk of ET (RR = 1.63; 95% CI, 1.19-2.23) but a decreased risk of PV (RR = 0.58; 95% CI, 0.34-0.98). There were no statistically significant associations of oral contraceptives or reproductive factors with MPN risk overall, or by MPN subtype. Bilateral oophorectomy was associated with increased risk of ET (RR = 1.58; 95% CI, 1.11-2.25) and decreased risk of PV (RR = 0.32; 95% CI, 0.12-0.88). There was no association of ovulatory years with ET risk; however, there was increased risk of PV (RR = 1.68 for >36.8 compared with ≤27.6 years; P trend = 0.045). Adjustment for potential confounding factors did not alter these associations. Conclusions: HT use and bilateral oophorectomy had opposite associations for ET and PV. Except for ovulatory years and PV risk, reproductive history did not appear to play a role in the etiology of MPN. Impact: This study suggests different mechanistic impacts of estrogen, and perhaps distinct etiologies, for the two major MPN subtypes.

AB - Background: Hormonal and reproductive history has been associated with risk of some hematologic malignancies, but their role in myeloproliferative neoplasms (MPN) is largely unknown. Methods: Using a population-based cohort study, we evaluated the association of these factors with risk of MPN overall, and for essential thrombocythemia (ET) and polycythemia vera (PV) specifically. Incident MPN cases from 1993 to 2004 were identified via linkage to Medicare. RR and 95% confidence intervals (CI) were estimated utilizing Cox proportional hazard regression. Results: After >250,000 person-years of follow-up, 257 cases of MPN were identified (172 ET, 64 PV). Ever use of hormone therapy (HT) was associated with an increased risk of ET (RR = 1.63; 95% CI, 1.19-2.23) but a decreased risk of PV (RR = 0.58; 95% CI, 0.34-0.98). There were no statistically significant associations of oral contraceptives or reproductive factors with MPN risk overall, or by MPN subtype. Bilateral oophorectomy was associated with increased risk of ET (RR = 1.58; 95% CI, 1.11-2.25) and decreased risk of PV (RR = 0.32; 95% CI, 0.12-0.88). There was no association of ovulatory years with ET risk; however, there was increased risk of PV (RR = 1.68 for >36.8 compared with ≤27.6 years; P trend = 0.045). Adjustment for potential confounding factors did not alter these associations. Conclusions: HT use and bilateral oophorectomy had opposite associations for ET and PV. Except for ovulatory years and PV risk, reproductive history did not appear to play a role in the etiology of MPN. Impact: This study suggests different mechanistic impacts of estrogen, and perhaps distinct etiologies, for the two major MPN subtypes.

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Hormonal and reproductive factors and risk of myeloproliferative neoplasms in postmenopausal women

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