TY - JOUR
T1 - Hormonal release of programmed behavior in silk moths
T2 - Probable mediation by cyclic AMP
AU - Truman, James W.
AU - Marie Fallon, Ann
AU - Wyatt, G. R.
PY - 1976
Y1 - 1976
N2 - The eclosion hormone triggers a stereotyped preprogrammed pattern of behavior in silk moths. The effects of the hormone were duplicated by the injection of dibutyryl adenosine 3′,5′-monophosphate, adenosine 3′,5′-monophosphate (cyclic AMP), or guanosine 3′,5′- monophosphate (cyclic GMP) into theophylline-treated pharate moths. Treatment with theophylline reduced the latency of the response to a low dose of hormone, presumably by blocking phosphodiesterase. Endogenous levels of cyclic AMP, but not cyclic GMP, increased significantly in the central nervous system within 10 minutes after hormone injection. We conclude that an early step leading to the release of the eclosion motor program is an increase in cyclic AMP in target neurons of the central nervous system.
AB - The eclosion hormone triggers a stereotyped preprogrammed pattern of behavior in silk moths. The effects of the hormone were duplicated by the injection of dibutyryl adenosine 3′,5′-monophosphate, adenosine 3′,5′-monophosphate (cyclic AMP), or guanosine 3′,5′- monophosphate (cyclic GMP) into theophylline-treated pharate moths. Treatment with theophylline reduced the latency of the response to a low dose of hormone, presumably by blocking phosphodiesterase. Endogenous levels of cyclic AMP, but not cyclic GMP, increased significantly in the central nervous system within 10 minutes after hormone injection. We conclude that an early step leading to the release of the eclosion motor program is an increase in cyclic AMP in target neurons of the central nervous system.
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U2 - 10.1126/science.188130
DO - 10.1126/science.188130
M3 - Article
C2 - 188130
AN - SCOPUS:0017149356
SN - 0036-8075
VL - 194
SP - 1432
EP - 1434
JO - Science
JF - Science
IS - 4272
ER -