TY - JOUR
T1 - Host defense in oral and airway epithelia
T2 - Chromosome 20 contributes a new protein family
AU - Bingle, Colin D.
AU - Gorr, Sven U.
PY - 2004/11
Y1 - 2004/11
N2 - The innate immune response is of pivotal importance in defending the mucosal barriers of the body against pathogenic attack. The list of proteins that contribute to this defense mechanism is constantly being updated. In this review we introduce a novel family of secreted proteins, palate, lung, and nasal epithelium clones (PLUNCs), that are expressed in the mouth, nose and upper airways of humans, mice, rats and cows. In humans, PLUNC genes are located in a compact cluster on chromosome 20, with similar loci being found in synteneic locations in other species. The protein products of this gene cluster are predicted to be structural homologues of the human lipopolysaccharide binding proteins, lipopolysaccharide binding-protein (LBP) and bacterial permeability-increasing protein (BPI), which are known mediators of host defense against Gram-negative bacteria. On the basis of these observations we outline why we believe PLUNC proteins mediate host defense functions in the oral, nasal and respiratory epithelia.
AB - The innate immune response is of pivotal importance in defending the mucosal barriers of the body against pathogenic attack. The list of proteins that contribute to this defense mechanism is constantly being updated. In this review we introduce a novel family of secreted proteins, palate, lung, and nasal epithelium clones (PLUNCs), that are expressed in the mouth, nose and upper airways of humans, mice, rats and cows. In humans, PLUNC genes are located in a compact cluster on chromosome 20, with similar loci being found in synteneic locations in other species. The protein products of this gene cluster are predicted to be structural homologues of the human lipopolysaccharide binding proteins, lipopolysaccharide binding-protein (LBP) and bacterial permeability-increasing protein (BPI), which are known mediators of host defense against Gram-negative bacteria. On the basis of these observations we outline why we believe PLUNC proteins mediate host defense functions in the oral, nasal and respiratory epithelia.
KW - Airway
KW - Bacterial permeability-increasing protein
KW - Epithelia
KW - Host defence
KW - Innate immunity
KW - Lipopolysaccharide binding-protein
KW - Oral
KW - PLUNC
KW - Parotid secretory protein
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U2 - 10.1016/j.biocel.2004.05.002
DO - 10.1016/j.biocel.2004.05.002
M3 - Review article
C2 - 15313462
AN - SCOPUS:4143135448
SN - 1357-2725
VL - 36
SP - 2144
EP - 2152
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
IS - 11
ER -