Host inflammatory response governs fitness in an avian ectoparasite, the northern fowl mite (Ornithonyssus sylviarum)

Jeb P. Owen, Mary E. Delany, Carol J. Cardona, Arthur A. Bickford, Bradley A. Mullens

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Vertebrate immune responses to ectoparasites influence pathogen transmission and host fitness costs. Few studies have characterized natural immune responses to ectoparasites and resultant fitness effects on the ectoparasite. These are critical gaps in understanding vertebrate-ectoparasite interaction, disease ecology and host-parasite co-adaptation. This study focused on an ectoparasite of birds-the northern fowl mite (NFM) (Ornithonyssus sylviarum). Based on prior evidence that chickens develop resistance to NFM, these experiments tested two hypotheses: (i) skin inflammation blocks mite access to blood, impairing development, reproduction and survival; and (ii) host immunogenetic variation influences the inflammatory response and subsequent effects on the ectoparasite. On infested hosts, histology of skin inflammation revealed increased epidermal cell number and size, immigration of leukocytes and deposition of serous exudates on the skin surface. Survival of adult mites and their offspring decreased as the area of skin inflammation increased during an infestation. Inflammation increased the distance to blood vessels beyond the length of mite mouthparts (100-160 μm) and prevented protonymphs and adults from reaching a blood source. Consequently, protonymphs could not complete development, evidenced by a significant inverse relationship between inflammation and protonymph feeding success, as well as an increasing protonymph/adult ratio. Adult females were unable to feed and reproduce, indicated by an inverse relationship between inflammation and egg production, and decreasing female/juvenile ratio. These combined impacts of host inflammation reversed NFM population growth. Intensity of inflammation was influenced by the genotype of the major histocompatibility complex (MHC), supporting previous research that linked these immunological loci with NFM resistance. Overall, these data provide a model for a mechanism of avian resistance to an ectoparasitic arthropod and the fitness costs to the parasite of that host defense.

Original languageEnglish (US)
Pages (from-to)789-799
Number of pages11
JournalInternational Journal for Parasitology
Volume39
Issue number7
DOIs
StatePublished - Jun 2009

Bibliographical note

Funding Information:
This work was supported by a grant from the US Department of Agriculture, National Research Initiative (USDA Cooperative State Research, Education and Extension Service, Grant No. #2005-35302-16341). We thank Dr. Janet Fulton (Hy-Line International) for guidance on MHC genotyping and Kimberly Klingler for supporting the genotyping. We also thank Lisa Gonzales, Martie Pastor and Kathryn Haith for help with animal care and processing samples and Andrew Ernst and Jason Mottern for Photographic assistance. Finally, we would like to sincerely thank two anonymous reviewers for considerable help with improving the manuscript.

Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.

Keywords

  • Co-adaptation
  • Ecological immunology
  • Ectoparasite
  • Inflammation
  • MHC
  • Ornithonyssus
  • Poultry
  • Resistance

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