The ability of fungal pathogens to cause disease is dependent on the ability to grow within the human host environment. In general, the human host environment can be considered a slightly alkaline environment, and the ability of fungi to grow at this pH is essential for pathogenesis. The Rim101 signal transduction pathway is the primary pH sensing pathway described in the pathogenic fungi, and in Candida albicans, it is required for a variety of diseases. As more detailed analyses have been conducted studying pathogenesis at the molecular level, it has become clear that the Rim101 pathway, and pH responses in general, play an intimate role in pathogenesis beyond simply allowing the organism to grow. Here, several recent advances into Rim101-dependent functions implicated in disease progression are discussed.
Bibliographical noteFunding Information:
Thank you to Lucia F Zacchi, Julie M Wolf, and Dr Jonathon Gomez-Raja for critical review of the manuscript. Some of the works described in this manuscript were supported in part by the Investigators in Pathogenesis of Infectious Disease Award from the Burroughs Wellcome Fund and by the NIH National Institute of Allergy and Infectious Disease Award 1R01-AI064054.
Copyright 2009 Elsevier B.V., All rights reserved.