Abstract
β-Defensin 3 (BD3) was identified as a ligand for the melanocortin receptors (MCRs) in 2007, although the pharmacology activity of BD3 has not been clearly elucidated. Herein, it is demonstrated that human BD3 and mouse BD3 are full micromolar agonists at the MCRs. Furthermore, mouse β-defensin 1 (BD1) and human BD1 are also MCR micromolar agonists. This work identifies BD1 as an endogenous MCR ligand and clarifies the controversial role of BD3 as a micromolar agonist.
Original language | English (US) |
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Pages (from-to) | 3738-3744 |
Number of pages | 7 |
Journal | Journal of medicinal chemistry |
Volume | 61 |
Issue number | 8 |
DOIs | |
State | Published - Apr 26 2018 |
Bibliographical note
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