Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases

Lucia Olcese, Paul Lang, Frédéric Vély, Anna Cambiaggi, Didier Marguet, Mathieu Bléry, Keli L. Hippen, Roberto Biassoni, Alessandro Moretta, Lorenzo Moretta, John C. Cambier, Eric Vivier

Research output: Contribution to journalArticlepeer-review

302 Scopus citations

Abstract

NK cells express cell surface receptors for MHC class I proteins (KIR). Engagement of these receptors inhibits NK cell cytotoxic programs. KIR can be expressed on T cells, and their engagement also results in inhibition of effector functions initiated by the CD3/TCR complex. While human KIR genes belong to the Ig gene superfamily, mouse KIR belong to a family of dimeric lectins. Despite these distinct evolutionary origins, we show here that both HLA-Cw3-specific human p58.183 receptors and H-2D(d/k)-specific mouse Ly49A receptors recruit the same protein tyrosine phosphatases, PTP1C and PTP1D, upon phosphorylation of critical intracytoplasmic tyrosine residues. These results document a common pathway by which diverse KIR can down-regulate NK and T cell activation programs, and further define the sequence of the immunoreceptor tyrosine-based inhibitory motif (ITIM), initially described in FcγRIIB1, and expressed in both human and mouse KIR.

Original languageEnglish (US)
Pages (from-to)4531-4534
Number of pages4
JournalJournal of Immunology
Volume156
Issue number12
StatePublished - Jun 15 1996

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