Human CD4+ CD45RA+ T lymphocytes can be stimulated by crocidolite, anthophyllite and amosite asbestos in vitro

Y. Watanabe, M. Yamaguchi, Y. Kawakami, F. Hyodoh, H. Tsushima, G. Ohsawa, A. Ueki

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Crocidolite, anthophyllite and amosite asbestos stimulate T lymphocyte subsets. Cell surface CD4 or CD45RA expression in peripheral blood mononuclear cells (PBMC) was downregulated temporarily after incubation with asbestos in vitro. The percentage of CD4+ CD45RA+ cells significantly decreased 12 h after incubation with asbestos, suggesting activation of the cells. An early increase in the intracellular Ca++ level was also indicative of activation. An elevated Ca++ level was observed after incubation in both PBMC and purified T cell fractions.

Original languageEnglish (US)
Pages (from-to)209-212
Number of pages4
JournalInternational Journal of Oncology
Volume2
Issue number2
StatePublished - Feb 5 1993

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