Human CD4+ CD45RA+ T lymphocytes can be stimulated by crocidolite, anthophyllite and amosite asbestos in vitro

Y. Watanabe; M. Yamaguchi; Y. Kawakami; F. Hyodoh; H. Tsushima; G. Ohsawa; A. Ueki

Human CD4⁺ CD45RA⁺ T lymphocytes can be stimulated by crocidolite, anthophyllite and amosite asbestos in vitro

Y. Watanabe, M. Yamaguchi, Y. Kawakami, F. Hyodoh, H. Tsushima, G. Ohsawa, A. Ueki

Genetics, Cell Biology and Development (TMED)

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6 Scopus citations

Abstract

Crocidolite, anthophyllite and amosite asbestos stimulate T lymphocyte subsets. Cell surface CD4 or CD45RA expression in peripheral blood mononuclear cells (PBMC) was downregulated temporarily after incubation with asbestos in vitro. The percentage of CD4⁺ CD45RA⁺ cells significantly decreased 12 h after incubation with asbestos, suggesting activation of the cells. An early increase in the intracellular Ca⁺⁺ level was also indicative of activation. An elevated Ca⁺⁺ level was observed after incubation in both PBMC and purified T cell fractions.

Original language	English (US)
Pages (from-to)	209-212
Number of pages	4
Journal	International Journal of Oncology
Volume	2
Issue number	2
State	Published - Feb 5 1993

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title = "Human CD4+ CD45RA+ T lymphocytes can be stimulated by crocidolite, anthophyllite and amosite asbestos in vitro",

abstract = "Crocidolite, anthophyllite and amosite asbestos stimulate T lymphocyte subsets. Cell surface CD4 or CD45RA expression in peripheral blood mononuclear cells (PBMC) was downregulated temporarily after incubation with asbestos in vitro. The percentage of CD4+ CD45RA+ cells significantly decreased 12 h after incubation with asbestos, suggesting activation of the cells. An early increase in the intracellular Ca++ level was also indicative of activation. An elevated Ca++ level was observed after incubation in both PBMC and purified T cell fractions.",

author = "Y. Watanabe and M. Yamaguchi and Y. Kawakami and F. Hyodoh and H. Tsushima and G. Ohsawa and A. Ueki",

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T1 - Human CD4+ CD45RA+ T lymphocytes can be stimulated by crocidolite, anthophyllite and amosite asbestos in vitro

AU - Watanabe, Y.

AU - Yamaguchi, M.

AU - Kawakami, Y.

AU - Hyodoh, F.

AU - Tsushima, H.

AU - Ohsawa, G.

AU - Ueki, A.

PY - 1993/2/5

Y1 - 1993/2/5

N2 - Crocidolite, anthophyllite and amosite asbestos stimulate T lymphocyte subsets. Cell surface CD4 or CD45RA expression in peripheral blood mononuclear cells (PBMC) was downregulated temporarily after incubation with asbestos in vitro. The percentage of CD4+ CD45RA+ cells significantly decreased 12 h after incubation with asbestos, suggesting activation of the cells. An early increase in the intracellular Ca++ level was also indicative of activation. An elevated Ca++ level was observed after incubation in both PBMC and purified T cell fractions.

AB - Crocidolite, anthophyllite and amosite asbestos stimulate T lymphocyte subsets. Cell surface CD4 or CD45RA expression in peripheral blood mononuclear cells (PBMC) was downregulated temporarily after incubation with asbestos in vitro. The percentage of CD4+ CD45RA+ cells significantly decreased 12 h after incubation with asbestos, suggesting activation of the cells. An early increase in the intracellular Ca++ level was also indicative of activation. An elevated Ca++ level was observed after incubation in both PBMC and purified T cell fractions.

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ER -

Human CD4⁺ CD45RA⁺ T lymphocytes can be stimulated by crocidolite, anthophyllite and amosite asbestos in vitro

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