Abstract
The effect of human cytomegalovirus (HCMV) gene expression on beta interferon (IFN-β) expression was examined. We demonstrate that the HCMV immediate-early 2 (IE2) gene product IE86 can effectively block the induction of IFN-β during HCMV infection. IE86 also efficiently blocked the induction of IFN-β following Sendai virus infection, demonstrating that IE86's ability to block induction of IFN-β is not limited to HCMV infection, identifying IE2 as an IFN-β antagonist.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3873-3877 |
| Number of pages | 5 |
| Journal | Journal of virology |
| Volume | 79 |
| Issue number | 6 |
| DOIs | |
| State | Published - Mar 2005 |