TY - JOUR
T1 - Human embryonic stem cells
T2 - A potential source of transplantable neural progenitor cells
AU - Guillaume, Daniel J.
AU - Zhang, Su Chun
PY - 2008/3
Y1 - 2008/3
N2 - The primary therapeutic goal of embryonic stem cell (ESC) research is cell replacement therapy. During the last decade, great strides have been made in developing in vitro protocols for differentiating human ESCs into neuroepithelial progenitors. More recent progress has been made in further directing them into becoming cells with specialized regional and neurotransmitter identities, such as midbrain dopaminergic and spinal motor neurons. Along with directed differentiation, other current efforts are aimed at efficient enrichment, avoidance of immune rejection, demonstration of functional integration, genetic modification to regulate neurotransmitter and factor release, directed axon growth, in vivo cell tracking, and measures to ensure safety. This review will focus on the potential of ESCs as a source of transplantable cells for use in cell replacement therapy.
AB - The primary therapeutic goal of embryonic stem cell (ESC) research is cell replacement therapy. During the last decade, great strides have been made in developing in vitro protocols for differentiating human ESCs into neuroepithelial progenitors. More recent progress has been made in further directing them into becoming cells with specialized regional and neurotransmitter identities, such as midbrain dopaminergic and spinal motor neurons. Along with directed differentiation, other current efforts are aimed at efficient enrichment, avoidance of immune rejection, demonstration of functional integration, genetic modification to regulate neurotransmitter and factor release, directed axon growth, in vivo cell tracking, and measures to ensure safety. This review will focus on the potential of ESCs as a source of transplantable cells for use in cell replacement therapy.
KW - CNS cell transplantation
KW - Cell replacement therapy
KW - Directed neural differentiation
KW - Embryonic stem cells
KW - Restorative neurosurgery
UR - http://www.scopus.com/inward/record.url?scp=42149116544&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42149116544&partnerID=8YFLogxK
U2 - 10.3171/FOC/2008/24/3-4/E1
DO - 10.3171/FOC/2008/24/3-4/E1
M3 - Review article
C2 - 18341406
AN - SCOPUS:42149116544
VL - 24
JO - Neurosurgical Focus
JF - Neurosurgical Focus
SN - 1092-0684
IS - 3-4
M1 - E2
ER -