Human genital papilloma infections: An evaluation of immunologic competence in the genital neoplasia-papilloma syndrome

Linda F Carson, Leo B. Twiggs, Michio Fukushima, Ronald S. Ostrow, Anthony J. Faras, Takashi Okagaki

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Immunologic evaluations of women with genital neoplasia-papilloma syndrome demonstrated the presence of subclinical immunodeficiency when compared with results in 20 control womenn. All patients with genital neoplasia-papilloma syndrome were previously found to have human papillomavirus deoxyribonucleic acid in genital neoplasias or papillomas occurring either synchronously (in at least two genital organs at the same time) or metachronously (at different times during a period of months to years). Immunologic tests included blastogenic responses of lymphocytes to mitogens (phytohemagglutinin, concanavalin A, pokeweed mitogen, and tetanus antigen) and lymphocyte phenotyping with the use of monoclonal antibodies (OKT3, OKT4, OKT8, and OKT11). As compared with those of control subjects, the responses of the lymphocytes of patients with genital neoplasia-papilloma syndrome to mitogens were significantly decreased. The group with genital neoplasia-papilloma syndrome had a significantly higher percentage of suppressor-cytotoxic T cells (OKT8-positive cells) when compared with that of control subjects (mean 33% versus 18%) and a lower proportion of helper T cells (OKT4-positive cells) when compared with that of control subjects (35% versus 50%). The mean helper-to-suppressorlcytotoxic T-cell ratio (mean OKT4/OKT8 ratio) in the human papillomavirus-infected women was 1.72 ± 0.29 (SE) as compared with 3.21 ± 0.33 (SE) in the control group, demonstrating a significant reduction of the ratio in the patients with genital neoplasia-papilloma syndrome. These findings suggest that patients with genital neoplasiapapilloma syndrome have a reduced suppressorlcytotoxic T-cell ratio (mean OKT4/OKT8 ratio; that in the human papillomavirus-infected women was 1.72 ± 0.29 (SE) as compared with 3.21 ± 0.33 (SE) in the control group, demonstrating a significant reduction of the ratio in patients with genital neoplasia-papilloma syndrome. These findings suggest that patients with genital neoplasia-papilloma syndrome have reduced immunocompetence of unknown etiology.

Original languageEnglish (US)
Pages (from-to)784-789
Number of pages6
JournalAmerican journal of obstetrics and gynecology
Volume155
Issue number4
DOIs
StatePublished - 1986

Bibliographical note

Funding Information:
From the Departments of Obstetrics and Gynecology, Laboratory Med-icine and Pathology, and Microbiology and the I nstitutefor Human Genetics, University of Minnesota Medical School. Funded by National Institutes of Health Grant CA25462 and the Minnesota Leukemia Research Fund. Presented at the Thirty-second Annual Meeting of the Society for Gynecologic Investigation, Phoenix, Arizona, March 20-23, 198 5. Received for publication January 31, 1986; revised May 9, 1986; accepted May 20, 1986. Reprint requests: Linda F. Carson, M.D., Instructor, Box 395 Mayo, Department of Obstetrics and Gynecology, University of Minnesota, Minneapolis, MN 55455.

Keywords

  • Papilloma
  • immunocompetence
  • neoplasm

Fingerprint

Dive into the research topics of 'Human genital papilloma infections: An evaluation of immunologic competence in the genital neoplasia-papilloma syndrome'. Together they form a unique fingerprint.

Cite this