TY - JOUR
T1 - Human granulocytic anaplasmosis and macrophage activation
AU - Dumler, J. Stephen
AU - Barat, Nicole C.
AU - Barat, Christopher E.
AU - Bakken, Johan S.
PY - 2007/7/15
Y1 - 2007/7/15
N2 - Patients with human granulocytic anaplasmosis present with fever, thrombocytopenia, leukopenia, and an elevated aspartate transaminase level. Clinical and histopathologic features of severe disease suggest macrophage activation. Twenty-nine patients with human granulocytic anaplasmosis had higher ferritin, interleukin-10, interleukin-12 p70, and interferon-γ levels than did control subjects matched for age and sex; severity correlated with triglyceride, ferritin, and interleukin-12 p70 levels. Several severely affected patients had cases that fulfilled macrophage activation syndrome diagnostic criteria. Macrophage activation and excessive cytokine production may belie tissue injury associated with Ananplasma phagocytophilum infection.
AB - Patients with human granulocytic anaplasmosis present with fever, thrombocytopenia, leukopenia, and an elevated aspartate transaminase level. Clinical and histopathologic features of severe disease suggest macrophage activation. Twenty-nine patients with human granulocytic anaplasmosis had higher ferritin, interleukin-10, interleukin-12 p70, and interferon-γ levels than did control subjects matched for age and sex; severity correlated with triglyceride, ferritin, and interleukin-12 p70 levels. Several severely affected patients had cases that fulfilled macrophage activation syndrome diagnostic criteria. Macrophage activation and excessive cytokine production may belie tissue injury associated with Ananplasma phagocytophilum infection.
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U2 - 10.1086/518834
DO - 10.1086/518834
M3 - Article
C2 - 17578779
AN - SCOPUS:34447092631
SN - 1058-4838
VL - 45
SP - 199
EP - 204
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 2
ER -