Human granulocytic ehrlichiosis

Johan S. Bakken, J. Stephen Dumler

Research output: Contribution to journalArticlepeer-review

184 Scopus citations

Abstract

Human granulocytic ehrlichiosis is a recently recognized tick-borne infectious disease, and to date >600 patients have been identified in the United States and Europe. Most patients have presented with a non-specific febrile illness occurring within 4 weeks after tick exposure or tick bite. The risk for serious illness or death increases with advancing age and delayed onset of therapy. Routine laboratory testing may reveal reduced white blood cell and platelet concentrations and mildly elevated hepatic transaminase activity in peripheral blood. A high index of suspicion is necessary to arrive at a timely clinical diagnosis. Patients suspected of having human granulocytic ehrlichiosis (HGE) should be treated with a tetracycline-class antibiotic while awaiting the outcome of confirmatory laboratory testing.

Original languageEnglish (US)
Pages (from-to)554-560
Number of pages7
JournalClinical Infectious Diseases
Volume31
Issue number2
DOIs
StatePublished - 2000

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