Human-origin influenza A(H3N2) reassortant viruses in Swine, southeast Mexico

Martha I. Nelson, Carine K. Souza, Nídia S. Trovão, Andres Diaz, Ignacio Mena, Albert Rovira, Amy L. Vincent, Montserrat Torremorell, Douglas Marthaler, Marie R. Culhane

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The genetic diversity of influenza A viruses circulating in swine in Mexico complicates control efforts in animals and presents a threat to humans, as shown by influenza A(H1N1)pdm09 virus. To describe evolution of swine influenza A viruses in Mexico and evaluate strains for vaccine development, we sequenced the genomes of 59 viruses and performed antigenic cartography on strains from 5 regions. We found that genetic and antigenic diversity were particularly high in southeast Mexico because of repeated introductions of viruses from humans and swine in other regions in Mexico. We identified novel reassortant H3N2 viruses with genome segments derived from 2 different viruses that were independently introduced from humans into swine: pandemic H1N1 viruses and seasonal H3N2 viruses. The Mexico swine viruses are antigenically distinct from US swine lineages. Protection against these viruses is unlikely to be afforded by US virus vaccines and would require development of new vaccines specifically targeting these diverse strains.

Original languageEnglish (US)
Pages (from-to)691-700
Number of pages10
JournalEmerging infectious diseases
Volume25
Issue number4
DOIs
StatePublished - Apr 2019

Bibliographical note

Funding Information:
Whole-genome sequencing for this study was generously sponsored by Zoetis Latin America through an agreement with the University of Minnesota (SOW 140-N-3545181). Evolutionary and antigenic analyses were supported by the Center for Research on Influenza Pathogenesis, a National Institute of Allergy and Infectious Diseases–funded Center of Excellence in Influenza Research and Pathogenesis (contract #HHSN272201400008C). This study was supported in part by an in-house collaborative research network for the study of influenza virus epidemiology and evolution (MISMS) led by the Fogarty International Center, National Institutes of Health.

Funding Information:
We thank all swine producers who contributed viruses for this study. Whole-genome sequencing for this study was generously sponsored by Zoetis Latin America through an agreement with the University of Minnesota (SOW 140-N-3545181). Evolutionary and antigenic analyses were supported by the Center for Research on Influenza Pathogenesis, a National Institute of Allergy and Infectious Diseases–funded Center of Excellence in Influenza Research and Pathogenesis (contract #HHSN272201400008C). This study was supported in part by an in-house collaborative research network for the study of influenza virus epidemiology and evolution (MISMS) led by the Fogarty International Center, National Institutes of Health.

Publisher Copyright:
© 2019, Centers for Disease Control and Prevention (CDC). All rights reserved.

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