Human-Phosphate-Binding-Protein inhibits HIV-1 gene transcription and replication

Thomas Cherrier; Mikael Elias; Alicia Jeudy; Guillaume Gotthard; Valentin Le Douce; Houda Hallay; Patrick Masson; Andrea Janossy; Ermanno Candolfi; Olivier Rohr; Eric Chabrière; Christian Schwartz

doi:10.1186/1743-422X-8-352

Human-Phosphate-Binding-Protein inhibits HIV-1 gene transcription and replication

Thomas Cherrier, Mikael Elias, Alicia Jeudy, Guillaume Gotthard, Valentin Le Douce, Houda Hallay, Patrick Masson, Andrea Janossy, Ermanno Candolfi, Olivier Rohr, Eric Chabrière, Christian Schwartz

Biochemistry, Molecular Biology, and Biophysics (CBS)

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Abstract. The Human Phosphate-Binding protein (HPBP) is a serendipitously discovered lipoprotein that binds phosphate with high affinity. HPBP belongs to the DING protein family, involved in various biological processes like cell cycle regulation. We report that HPBP inhibits HIV-1 gene transcription and replication in T cell line, primary peripherical blood lymphocytes and primary macrophages. We show that HPBP is efficient in nave and HIV-1 AZT-resistant strains. Our results revealed HPBP as a new and potent anti HIV molecule that inhibits transcription of the virus, which has not yet been targeted by HAART and therefore opens new strategies in the treatment of HIV infection.

Original language	English (US)
Article number	352
Journal	Virology journal
Volume	8
DOIs	https://doi.org/10.1186/1743-422X-8-352
State	Published - 2011

Bibliographical note

Funding Information:
This work was supported by grants from the Agence Nationale de Recherche sur le SIDA (ANRS), Sidaction and Institut Universitaire de France to OR and from CNRS to TC. ME is a fellow supported by the IEF Marie Curie program (grant No. 252836). TC is a fellow supported by the Belgian Fund for Scientific Research (FRS-FNRS, Belgium). Andrea J is a fellow supported by the “Région Alsace”. VLD is supported by a doctoral grant from the French Ministry of Research.

Keywords

HAART
HIV-1
HPBP
transcription

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Human-Phosphate-Binding-Protein inhibits HIV-1 gene transcription and replication",

abstract = "Abstract. The Human Phosphate-Binding protein (HPBP) is a serendipitously discovered lipoprotein that binds phosphate with high affinity. HPBP belongs to the DING protein family, involved in various biological processes like cell cycle regulation. We report that HPBP inhibits HIV-1 gene transcription and replication in T cell line, primary peripherical blood lymphocytes and primary macrophages. We show that HPBP is efficient in nave and HIV-1 AZT-resistant strains. Our results revealed HPBP as a new and potent anti HIV molecule that inhibits transcription of the virus, which has not yet been targeted by HAART and therefore opens new strategies in the treatment of HIV infection.",

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note = "Funding Information: This work was supported by grants from the Agence Nationale de Recherche sur le SIDA (ANRS), Sidaction and Institut Universitaire de France to OR and from CNRS to TC. ME is a fellow supported by the IEF Marie Curie program (grant No. 252836). TC is a fellow supported by the Belgian Fund for Scientific Research (FRS-FNRS, Belgium). Andrea J is a fellow supported by the “R{\'e}gion Alsace”. VLD is supported by a doctoral grant from the French Ministry of Research.",

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doi = "10.1186/1743-422X-8-352",

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AU - Cherrier, Thomas

AU - Elias, Mikael

AU - Jeudy, Alicia

AU - Gotthard, Guillaume

AU - Le Douce, Valentin

AU - Hallay, Houda

AU - Masson, Patrick

AU - Janossy, Andrea

AU - Candolfi, Ermanno

AU - Rohr, Olivier

AU - Chabrière, Eric

AU - Schwartz, Christian

N1 - Funding Information: This work was supported by grants from the Agence Nationale de Recherche sur le SIDA (ANRS), Sidaction and Institut Universitaire de France to OR and from CNRS to TC. ME is a fellow supported by the IEF Marie Curie program (grant No. 252836). TC is a fellow supported by the Belgian Fund for Scientific Research (FRS-FNRS, Belgium). Andrea J is a fellow supported by the “Région Alsace”. VLD is supported by a doctoral grant from the French Ministry of Research.

PY - 2011

Y1 - 2011

N2 - Abstract. The Human Phosphate-Binding protein (HPBP) is a serendipitously discovered lipoprotein that binds phosphate with high affinity. HPBP belongs to the DING protein family, involved in various biological processes like cell cycle regulation. We report that HPBP inhibits HIV-1 gene transcription and replication in T cell line, primary peripherical blood lymphocytes and primary macrophages. We show that HPBP is efficient in nave and HIV-1 AZT-resistant strains. Our results revealed HPBP as a new and potent anti HIV molecule that inhibits transcription of the virus, which has not yet been targeted by HAART and therefore opens new strategies in the treatment of HIV infection.

AB - Abstract. The Human Phosphate-Binding protein (HPBP) is a serendipitously discovered lipoprotein that binds phosphate with high affinity. HPBP belongs to the DING protein family, involved in various biological processes like cell cycle regulation. We report that HPBP inhibits HIV-1 gene transcription and replication in T cell line, primary peripherical blood lymphocytes and primary macrophages. We show that HPBP is efficient in nave and HIV-1 AZT-resistant strains. Our results revealed HPBP as a new and potent anti HIV molecule that inhibits transcription of the virus, which has not yet been targeted by HAART and therefore opens new strategies in the treatment of HIV infection.

KW - HAART

KW - HIV-1

KW - HPBP

KW - transcription

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Human-Phosphate-Binding-Protein inhibits HIV-1 gene transcription and replication

Abstract

Bibliographical note

Keywords

UN SDGs

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