TY - JOUR
T1 - Hybrid matrix grafts to favor tissue regeneration in rabbit femur bone lesions
AU - Goy, Dante Pascual
AU - Gorosito, Emmanuel
AU - Costa, Hermes S.
AU - Mortarino, Pablo
AU - Pedemonte, Noelia Acosta
AU - Toledo, Javier
AU - Mansur, Herman S.
AU - Pereira, Marivalda M.
AU - Battaglino, Ricardo
AU - Feldman, Sara
PY - 2012/7/23
Y1 - 2012/7/23
N2 - At present, typical approaches employed to repair fractures and other bone lesions tend to use matrix grafts to promote tissue regeneration. These grafts act as templates, which promote cellular adhesion, growth and proliferation, osteoconduction, and even osteoinduction, which commonly results in de novo osteogenesis. The present work aimed to study the bone-repairing ability of hybrid matrixes (HM) prepared with polyvinyl alcohol (PVA) and bioactive glass in an experimental rabbit model. The HM were prepared by combining 30% bioactive glass (nominal composition of 58% SiO 2 -33 % CaO - 9% P 2O 5) and 70% PVA. New Zealand rabbits were randomly divided into the control group (C group) and two groups with bone lesions, in which one received a matrix implant HM (Implant group), while the other did not (no Implant group). Clinical monitoring showed no altered parameters from either the Implant or the no Implant groups as compared to the control group, for the variables of diet grades, day and night temperatures and hemograms. In the Implant group, radiologic and tomographic studies showed implanted areas with clean edges in femoral non-articular direction, and radio-dense images that suggest incipient integration. Minimum signs of phlogosis could be observed, whereas no signs of rejection at this imaging level could be identified. Histological analysis showed evidence of osteo-integration, with the formation of a trabecular bone within the implant. Together, these results show that implants of hybrid matrixes of bioactive glass are capable of promoting bone regeneration.
AB - At present, typical approaches employed to repair fractures and other bone lesions tend to use matrix grafts to promote tissue regeneration. These grafts act as templates, which promote cellular adhesion, growth and proliferation, osteoconduction, and even osteoinduction, which commonly results in de novo osteogenesis. The present work aimed to study the bone-repairing ability of hybrid matrixes (HM) prepared with polyvinyl alcohol (PVA) and bioactive glass in an experimental rabbit model. The HM were prepared by combining 30% bioactive glass (nominal composition of 58% SiO 2 -33 % CaO - 9% P 2O 5) and 70% PVA. New Zealand rabbits were randomly divided into the control group (C group) and two groups with bone lesions, in which one received a matrix implant HM (Implant group), while the other did not (no Implant group). Clinical monitoring showed no altered parameters from either the Implant or the no Implant groups as compared to the control group, for the variables of diet grades, day and night temperatures and hemograms. In the Implant group, radiologic and tomographic studies showed implanted areas with clean edges in femoral non-articular direction, and radio-dense images that suggest incipient integration. Minimum signs of phlogosis could be observed, whereas no signs of rejection at this imaging level could be identified. Histological analysis showed evidence of osteo-integration, with the formation of a trabecular bone within the implant. Together, these results show that implants of hybrid matrixes of bioactive glass are capable of promoting bone regeneration.
KW - Bioactive glass
KW - Bone regeneration
KW - Femur bone lesion
KW - Hybrid matrix
KW - Polyvinyl alcohol
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U2 - 10.2174/1874120701206010085
DO - 10.2174/1874120701206010085
M3 - Article
C2 - 22848334
AN - SCOPUS:84863904146
SN - 1874-1207
VL - 6
SP - 85
EP - 91
JO - Open Biomedical Engineering Journal
JF - Open Biomedical Engineering Journal
IS - 1
ER -