Inspired by dioxygen-activating iron or copper enzymes that catalyze a number of oxidative transformations, efforts in the past decade have focused on developing synthetic nonheme iron and copper catalysts that activate H2O2 for the hydroxylation of strong CH bonds and the epoxidation and cis-dihydroxylation of CC bonds. For iron catalysts, reaction conditions have been identified that allow for their use in natural products' syntheses, and the high stereoselectivity observed implicates a metal-based oxidant that is proposed to be an oxoiron(V) species. Progress on copper catalysts for hydrocarbon oxidation on the other hand is at a more rudimentary stage.
|Original language||English (US)|
|Title of host publication||Homogeneous Catalytic Applications|
|Number of pages||16|
|State||Published - Aug 2013|
Bibliographical noteFunding Information:
This work was supported by a grant from the US Department of Energy (DE-FG02-03ER15455).
- Alkane oxidation
- Bioinspired catalysis
- C-H activation
- Homogeneous catalysis
- Hydrocarbon oxidation
- Hydrogen peroxide
- Iron and copper catalysts
- Mechanistic studies