Hyperalgesia to heat after intradermal injection of capsaicin

Donald A. Simone; Jeffrey Y F Ngeow; Gerald J. Putterman; Robert H. LaMotte

doi:10.1016/0006-8993(87)90982-6

Hyperalgesia to heat after intradermal injection of capsaicin

Donald A. Simone, Jeffrey Y F Ngeow, Gerald J. Putterman, Robert H. LaMotte

Diagnostic and Biological Sciences

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108 Scopus citations

Abstract

Capsaicin injected intradermally into the human forearm lowered the pain threshold for heat at the injection site. Both the magnitude and duration of hyperalgesia were dose dependent over the range of 0.1-100 μg, given in a constant volume of 10 μl. Thus, capsaicin may be a useful tool in studies of the neural mechanisms of hyperalgesia.

Original language	English (US)
Pages (from-to)	201-203
Number of pages	3
Journal	Brain Research
Volume	418
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(87)90982-6
State	Published - Aug 18 1987

Keywords

Capsaicin
Chronic pain
Hyperalgesia
Nociception

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abstract = "Capsaicin injected intradermally into the human forearm lowered the pain threshold for heat at the injection site. Both the magnitude and duration of hyperalgesia were dose dependent over the range of 0.1-100 μg, given in a constant volume of 10 μl. Thus, capsaicin may be a useful tool in studies of the neural mechanisms of hyperalgesia.",

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AU - Simone, Donald A.

AU - Ngeow, Jeffrey Y F

AU - Putterman, Gerald J.

AU - LaMotte, Robert H.

PY - 1987/8/18

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AB - Capsaicin injected intradermally into the human forearm lowered the pain threshold for heat at the injection site. Both the magnitude and duration of hyperalgesia were dose dependent over the range of 0.1-100 μg, given in a constant volume of 10 μl. Thus, capsaicin may be a useful tool in studies of the neural mechanisms of hyperalgesia.

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KW - Chronic pain

KW - Hyperalgesia

KW - Nociception

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ER -

Hyperalgesia to heat after intradermal injection of capsaicin

Abstract

Keywords

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