Hyperalgesia to heat after intradermal injection of capsaicin

Donald A. Simone, Jeffrey Y F Ngeow, Gerald J. Putterman, Robert H. LaMotte

Research output: Contribution to journalArticlepeer-review

101 Scopus citations


Capsaicin injected intradermally into the human forearm lowered the pain threshold for heat at the injection site. Both the magnitude and duration of hyperalgesia were dose dependent over the range of 0.1-100 μg, given in a constant volume of 10 μl. Thus, capsaicin may be a useful tool in studies of the neural mechanisms of hyperalgesia.

Original languageEnglish (US)
Pages (from-to)201-203
Number of pages3
JournalBrain Research
Issue number1
StatePublished - Aug 18 1987


  • Capsaicin
  • Chronic pain
  • Hyperalgesia
  • Nociception

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