Hyperglycemia is associated with poor outcome in newborn infants undergoing therapeutic hypothermia for hypoxic ischemic encephalopathy

Nitin S. Chouthaia, Holly Sobczak, Reshma Khan, Divya Subramaniana, Sim Raman, Raghavendra Rao

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

BACKGROUND: Therapeutic hypothermia (TH) improves survival and neurodevelopmental outcome in neonatal hypoxic ischemic encephalopathy (HIE). Both, hypoglycemia and hyperglycemia are common in infants with HIE. The relationship between hypoglycemia and hyperglycemia, and immediate outcome has not been well described. METHODS: A retrospective analysis of newborn infants with HIE (N= 56) was conducted. Blood glucose concentrations recorded during the first 96 hours were noted. Glucose levels of infants who underwent TH (TH group, N= 20) were compared with those that did not undergo TH (No-TH group, N= 36). The relationship between blood glucose and mortality and/or moderate/severe disability was determined. RESULTS: Mean±SD blood glucose concentration during the first 24 hours of age was significantly higher in the TH group (148±65 mg/dl), compared with the No-TH group (113±50 mg/dl; p = 0.02), despite a lower glucose infusion rate in the former (4.05±1.77 mg/kg/hr vs. 5.36±2.51 mg/kg/hr; p = 0.04). One hundred percent of infants (n = 9) in the TH group with blood glucose levels >200 mg/dl during the first 24 hours of age died or had moderate/severe disability, compared with 54.5% of those with blood glucose <200 mg/dl in this group (p = 0.03). A similar effect was not present in the No-TH group. CONCLUSION: Hyperglycemia on the first day portends poor outcome in newborn infants undergoing TH for HIE.

Original languageEnglish (US)
Pages (from-to)125-131
Number of pages7
JournalJournal of Neonatal-Perinatal Medicine
Volume8
Issue number2
DOIs
StatePublished - Jul 31 2015

Keywords

  • Hypoxic ischemic encephalopathy
  • hyperglycemia
  • therapeutic hypothermia

Fingerprint Dive into the research topics of 'Hyperglycemia is associated with poor outcome in newborn infants undergoing therapeutic hypothermia for hypoxic ischemic encephalopathy'. Together they form a unique fingerprint.

Cite this