TY - JOUR
T1 - Hypocretin I in the lateral hypothalamus activates key feeding- regulatory brain sites
AU - Mullett, Mary A.
AU - Billington, Charles J.
AU - Levine, Allen S.
AU - Kotz, Catherine M.
PY - 2000/1/17
Y1 - 2000/1/17
N2 - Hypocretin I (also referred to as orexin A) administered into the lateral hypothalamus (LH) stimulates feeding in rats. We undertook the present study to determine the brain regions activated by LH administration of hypocretin I. Hypocretin I administered into the LH significantly elevated cFos-immunoreactivity in the lateral septal area, the central nucleus of the amygdala, the shell of the nucleus accumbens, the bed nucleus of the stria terminalis, the LH, the posterior and dorsomedial hypothalamus, the perifonical, arcuate and paraventricular nuclei and the nucleus of the solitary tract. These data indicate that LH hypocretin I communicates with other key energy regulatory sites within the hypothalamus, the limbic region and the hindbrain, and suggest that these areas are important in the feeding- stimulatory actions of hypocretin I.
AB - Hypocretin I (also referred to as orexin A) administered into the lateral hypothalamus (LH) stimulates feeding in rats. We undertook the present study to determine the brain regions activated by LH administration of hypocretin I. Hypocretin I administered into the LH significantly elevated cFos-immunoreactivity in the lateral septal area, the central nucleus of the amygdala, the shell of the nucleus accumbens, the bed nucleus of the stria terminalis, the LH, the posterior and dorsomedial hypothalamus, the perifonical, arcuate and paraventricular nuclei and the nucleus of the solitary tract. These data indicate that LH hypocretin I communicates with other key energy regulatory sites within the hypothalamus, the limbic region and the hindbrain, and suggest that these areas are important in the feeding- stimulatory actions of hypocretin I.
KW - Brain Pathways
KW - Hypocretin
KW - Lateral hypothalamus
KW - Orexin
KW - cFos immunohistochemistry, Feeding behavior
UR - http://www.scopus.com/inward/record.url?scp=0034677024&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034677024&partnerID=8YFLogxK
U2 - 10.1097/00001756-200001170-00021
DO - 10.1097/00001756-200001170-00021
M3 - Article
C2 - 10683839
AN - SCOPUS:0034677024
SN - 0959-4965
VL - 11
SP - 103
EP - 108
JO - Neuroreport
JF - Neuroreport
IS - 1
ER -