TY - JOUR
T1 - Hyponatremia Treatment Guidelines 2007
T2 - Expert Panel Recommendations
AU - Verbalis, Joseph G.
AU - Goldsmith, Stephen R.
AU - Greenberg, Arthur
AU - Schrier, Robert W.
AU - Sterns, Richard H.
PY - 2007/11
Y1 - 2007/11
N2 - Although hyponatremia is a common, usually mild, and relatively asymptomatic disorder of electrolytes, acute severe hyponatremia can cause substantial morbidity and mortality, particularly in patients with concomitant disease. In addition, overly rapid correction of chronic hyponatremia can cause severe neurologic deficits and death, and optimal treatment strategies for such cases are not established. An expert panel assessed the potential contributions of aquaretic nonpeptide small-molecule arginine vasopressin receptor (AVPR) antagonists to hyponatremia therapies. This review presents their conclusions, including identification of appropriate treatment populations and possible future indications for aquaretic AVPR antagonists.
AB - Although hyponatremia is a common, usually mild, and relatively asymptomatic disorder of electrolytes, acute severe hyponatremia can cause substantial morbidity and mortality, particularly in patients with concomitant disease. In addition, overly rapid correction of chronic hyponatremia can cause severe neurologic deficits and death, and optimal treatment strategies for such cases are not established. An expert panel assessed the potential contributions of aquaretic nonpeptide small-molecule arginine vasopressin receptor (AVPR) antagonists to hyponatremia therapies. This review presents their conclusions, including identification of appropriate treatment populations and possible future indications for aquaretic AVPR antagonists.
KW - Antidiuretic hormone
KW - Aquaretics
KW - Hypo-osmolality
KW - Natriuresis
KW - Syndrome of inappropriate antidiuretic hormone secretion
KW - Vasopressin
UR - http://www.scopus.com/inward/record.url?scp=35649016098&partnerID=8YFLogxK
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U2 - 10.1016/j.amjmed.2007.09.001
DO - 10.1016/j.amjmed.2007.09.001
M3 - Article
C2 - 17981159
AN - SCOPUS:35649016098
SN - 0002-9343
VL - 120
SP - S1-S21
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 11 SUPPL. 1
ER -