TY - JOUR
T1 - Hypoxic response is inversely related to degree of exercise hyperventilation
AU - Pianosi, Paul
AU - Marchione, Tony
PY - 1995/7
Y1 - 1995/7
N2 - The Dejours hyperoxic test has been used to quantitate peripheral chemoreceptor contribution to the hyperpnea of exercise. The strength of this drive, measured by the percent reduction in ventilation, varies among individuals and is lacking in chemodenervated humans, who also fail to manifest a hyperventilatory response in heavy exercise. We reasoned that greater hyperventilation in exercise above the anaerobic threshold ought to be associated with greater hypoxic (carotid body) drive. The present study tested this hypothesis. In 17 naive subjects, carotid body O2 chemosensitivity was tested repeatedly during exercise above the ventilatory anaerobic threshold (VAT) using 2 breaths of O2. The response to these transients was quantitated by the percentage change in ventilation, and exercise hyperventilation was quantitated by V̇E in excess of V̇CO2 predicted from the slope of Δ V ̇E Δ V ̇CO2 below VAT in incremental exercise. Contrary to expectations, there was an inverse relation between the degree of exercise hyperventilation and the percentage reduction in exercise ventilation in response to O2. The significance of this observation and its integration with current thinking of the role of the peripheral chemoreceptor in mediating hyperventilation of heavy exercise is discussed.
AB - The Dejours hyperoxic test has been used to quantitate peripheral chemoreceptor contribution to the hyperpnea of exercise. The strength of this drive, measured by the percent reduction in ventilation, varies among individuals and is lacking in chemodenervated humans, who also fail to manifest a hyperventilatory response in heavy exercise. We reasoned that greater hyperventilation in exercise above the anaerobic threshold ought to be associated with greater hypoxic (carotid body) drive. The present study tested this hypothesis. In 17 naive subjects, carotid body O2 chemosensitivity was tested repeatedly during exercise above the ventilatory anaerobic threshold (VAT) using 2 breaths of O2. The response to these transients was quantitated by the percentage change in ventilation, and exercise hyperventilation was quantitated by V̇E in excess of V̇CO2 predicted from the slope of Δ V ̇E Δ V ̇CO2 below VAT in incremental exercise. Contrary to expectations, there was an inverse relation between the degree of exercise hyperventilation and the percentage reduction in exercise ventilation in response to O2. The significance of this observation and its integration with current thinking of the role of the peripheral chemoreceptor in mediating hyperventilation of heavy exercise is discussed.
KW - Carotid body, O sensitivity
KW - Chemoreceptors, peripheral
KW - Control of breathing, exercise, O sensitivity
KW - Exercise
KW - Mammals, Human
KW - Oxygen, Sensitivity
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U2 - 10.1016/0034-5687(94)00136-N
DO - 10.1016/0034-5687(94)00136-N
M3 - Article
C2 - 8525123
AN - SCOPUS:0029115127
VL - 101
SP - 71
EP - 78
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
SN - 1569-9048
IS - 1
ER -