Abstract
Id1 and NF-κB are highly expressed in oral squamous cell carcinoma (OSCC). Whether they have a synergistic role in the carcinogenesis of OSCC is unclear. The current study was designed to demonstrate the synergy of both Id1 and NF-κ B in the underlying disease mechanisms of OSCC using in vitro and in vivo animal models. Id1 and NF-κ B strengthened the expression of both CD133 and BMI-1 in OSCC cell cultures. CD133+ and BMI-1+ keratinocytes from OSCC tissues and cell cultures initiated the growth of xenograft tumors in SCID/Beige mice. Id1 and NF-κB regulate the expression of CD133 and BMI-1 in an additive or synergistic manner in OSCC, which is associated with the generation of naïve and self-renewable keratinocytes and initiate the growth of xenograft tumors in vivo.
Original language | English (US) |
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Pages (from-to) | 1481-1489 |
Number of pages | 9 |
Journal | International Journal of Oncology |
Volume | 44 |
Issue number | 5 |
DOIs | |
State | Published - May 2014 |
Keywords
- Cancer stem-like cells
- Head and neck cancer
- Id1
- Nf-κb
- OCT4
- Oral squamous cell carcinoma