Identification of a dual specificity kinase that activates the jun kinases and p38-Mpk2

Anning Lin, Audrey Minden, Horacio Martinetto, Francois Xavier Claret, Carol Lange-Carter, Frank Mercurio, Gary L. Johnson, Michael Karin

Research output: Contribution to journalArticlepeer-review

692 Scopus citations

Abstract

One Ras-dependent protein kinase cascade leading from growth factor receptors to the ERK (extracellular signal-regulated kinases) subgroup of mitogen-activated protein kinases (MAPKs) is dependent on the protein kinase Raf-1, which activates the MEK (MAPK or ERK kinase) dual specificity kinases. A second protein kinase cascade leading to activation of the Jun kinases (JNKs) is dependent on MEKK (MEK kinase). A dual-specificity kinase that activates JNK, named JNKK, was identified that functions between MEKK and JNK. JNKK activated the JNKs but did not activate the ERKs and was unresponsive to Raf-1 in transfected HeLa cells. JNKK also activated another MAPK, p38 (Mpk2; the mammalian homolog of HOG1 from yeast), whose activity is regulated similarly to that of the JNKs.

Original languageEnglish (US)
Pages (from-to)286-290
Number of pages5
JournalScience
Volume268
Issue number5208
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

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