Identification of an N′-Nitrosonornicotine-Specific Deoxyadenosine Adduct in Rat Liver and Lung DNA

Medicine & Life Sciences

• N'-nitrosonornicotine 100%
• 2'-deoxyadenosine 84%
• Nitrosamines 69%
• pyridine 51%
• DNA 31%
• Lung 30%
• Liver 29%
• Hydroxylation 19%
• Tobacco 16%
• 5'-acetoxy-N'-nitrosonornicotine 14%
• DNA Adducts 14%
• Carcinogens 10%
• deoxyinosine 10%
• 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 8%
• Carcinogenesis 8%
• calf thymus DNA 8%
• International Agencies 7%
• Metabolic Activation 6%
• Laboratory Animals 6%
• Smoke 5%
• Mass Spectrometry 5%
• Ions 4%
• Biomarkers 3%
• Neoplasms 3%
• In Vitro Techniques 2%

Chemical Compounds

• Nitrosamine 74%
• Adduct 40%
• Metabolic Activation 8%
• Smoke 7%
• High Resolution Mass Spectrometry (HRMS) 6%
• Carcinogenic 6%
• Diastereomer 5%
• Biological Marker 5%
• Fragmentation 5%
• Reduction 2%
• Ion 2%