Identification of autoxidation and photodegradation products of ethynylestradiol by on-line HPLC-NMR and HPLC-MS

Brigitte E. Segmuller, Barbara L. Armstrong, Richard Dunphy, Alan R. Oyler

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

HPLC-NMR, HPLC-MS, and HPLC-UV were used to characterize the predominant solution autoxidation and photodegradation products of ethynylestradiol (1). A hydroperoxide (2) and a series of isomeric dimeric oxidation products (3-7), were identified. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)927-937
Number of pages11
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume23
Issue number5
DOIs
StatePublished - Oct 2000

Keywords

  • Autoxidation
  • Estrogen
  • Ethynylestradiol
  • HPLC-MS
  • HPLC-NMR
  • Photodegradation

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