Idiopathic Pulmonary Hemosiderosis: Ultrastructural Studies and Response to Azathioprine

Henry Yeager, Deborah Powell, Richard M. Weinberg, Heinz Bauer, Joseph A. Bellanti, Sol Katz

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Two boys are presented who fulfilled criteria for a diagnosis of idiopathic pulmonary hemosiderosis. A lung biopsy specimen from the first patient showed alveolar-capillary basement membrane abnormalities, together with abnormalities of capillary endothelial cells and hemosiderin-laden macrophages. A lung biopsy specimen from the second patient showed mainly capillary endothelial abnormalities and interstitial fibrosis. Both patients had a noticeable improvement in symptoms and relative stabilization of their roentgenographic and pulmonary function abnormalities following azathioprine therapy.

Original languageEnglish (US)
Pages (from-to)1145-1149
Number of pages5
JournalArchives of Internal Medicine
Volume136
Issue number10
DOIs
StatePublished - Oct 1976

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